Long non-coding RNA and transfer RNA-derived small fragments in exosomes are potential biomarkers for canine oral melanoma

Review Biochemistry & Molecular Biology

Small nucleolar RNA and its potential role in breast cancer - A comprehensive review

Venzil Lavie Dsouza et al.

Summary: snoRNAs play a critical role in regulating miRNA expression and their dysregulation is associated with breast cancer. Measuring snoRNA levels could be informative for the diagnosis and prognosis of breast cancer.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Review Cell Biology

Advances on liver cell-derived exosomes in liver diseases

Yan Jiao et al.

Summary: Exosomes are extracellular vesicles ranging in size from 30 to 150 nm, containing various proteins, mRNA, miRNA, and lipids which coordinate physiological and pathological functions through cell-to-cell communication. Specifically, liver cell-derived exosomes play a crucial role in both general physiological functions and the pathogenesis of liver diseases, making them potential diagnostic biomarkers and treatment targets.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Biotechnology & Applied Microbiology

DCI after Aneurysmal Subarachnoid Hemorrhage Is Related to the Expression of MFG-E8

Xianjun Chen et al.

Summary: The study found that MFG-E8 has significant predictive value for the occurrence of DCI after aSAH, with levels correlating with the risk of DCI. High levels of MFG-E8 may help reduce the incidence of DCI.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Oncology

Identification of melanoma-specific exosomal miRNAs as the potential biomarker for canine oral melanoma

Al Asmaul Husna et al.

Summary: This study identified several differentially expressed miRNAs in exosomes of canine melanoma cells, with certain miRNAs significantly increased in plasma exosomes of metastatic melanoma patients. These miRNAs could serve as potential biomarkers for identifying metastatic melanoma and improving prognosis, with sensitivity and specificity over 85% for distinguishing between non-metastatic and metastatic patients.

PIGMENT CELL & MELANOMA RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Ensembl 2021

Kevin L. Howe et al.

Summary: The Ensembl project provides genome annotation and data dissemination services for vertebrate species, including detailed annotation of gene structures, regulatory elements, and variants, as well as inferring the evolutionary history of genes and genomes. They offer integrated genomic data through various means such as genome browsers, search interfaces, specialist tools, and download files. Recent developments include the Ensembl Rapid Release and the SARS-CoV-2 genome browser, aiding in the international scientific response to the COVID-19 pandemic.

NUCLEIC ACIDS RESEARCH (2021)

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Article Veterinary Sciences