Auxin's origin: do PILS hold the key?

Auxin is a key regulator of many developmental processes in land plants and plays a strikingly similar role in the phylogenetically distant brown seaweeds. Emerging evidence shows that the PIN and PIN-like (PILS) auxin transporter families have preceded the evolution of the canonical auxin response pathway. A wide conservation of PILS-mediated auxin transport, together with reports of auxin function in unicellular algae, would suggest that auxin function preceded the advent of multicellularity. We find that PIN and PILS transporters form two eukaryotic subfamilies within a larger bacterial family. We argue that future functional characterisation of algal PIN and PILS transporters can shed light on a common origin of an auxin function followed by independent co-option in a multicellular context.

Automated summary

Auxin plays a crucial role in the development of land plants and brown seaweeds, and the PIN and PILS transporter families may have evolved prior to the canonical auxin response pathway. The conservation of PILS-mediated auxin transport and the existence of auxin function in unicellular algae suggest that auxin function predates multicellularity.