Journal
TRENDS IN NEUROSCIENCES
Volume 45, Issue 5, Pages 358-368Publisher
CELL PRESS
DOI: 10.1016/j.tins.2022.02.006
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Funding
- Netherlands Organization for Scientific Research [91718308]
- EUR fellowship
- Warren Alpert Foundation
- Encephalitis Society
- NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation
- Netherlands Organ-on-Chip Initiative
- NWO Gravitation project
- Ministry of Education, Culture and Science of the Government of The Netherlands [024.003.001]
- Dutch ZonMw More-Knowledge-with-Fewer-Animals (MKMD) [114025201]
- Erasmus MC Human Disease Model Award
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This article provides an overview of neurological complications associated with SARS-CoV-2 infection and discusses their pathogenesis. It outlines the distinctions between neuroinvasiveness, neurotropism, and neurovirulence, and explores the advantages and limitations of different experimental models in advancing the field.
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection is as-sociated with a diverse spectrum of neurological complications during the acute and postacute stages. The pathogenesis of these complications is complex and dependent on many factors. For accurate and consistent interpretation of exper-imental data in this fast-growing field of research, it is essential to use terminol-ogy consistently. In this article, we outline the distinctions between neuroinvasiveness, neurotropism, and neurovirulence. Additionally, we discuss current knowledge of these distinct features underlying the pathogenesis of SARS-CoV-2-associated neurological complications. Lastly, we briefly discuss the advantages and limitations of different experimental models, and how these approaches can further be leveraged to advance the field.
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