Cross-species considerations in models of neurodevelopmental disorders

Advances in genetic technologies have facilitated the development of new animal models of neuro-developmental disorders (NDDs), enabling cross-species validation of disease-related phenotypes and exploration of species-specific behaviours. In a recent study, Berg et al. used a rat model of Angelman Syndrome (AS) to identify Ube3a-dependent social behaviours, highlighting potential cross-species convergence and divergence between rodent models.

Automated summary

Advances in genetic technologies have led to the development of new animal models for studying neuro-developmental disorders, allowing researchers to validate disease-related phenotypes and explore species-specific behaviors. A recent study using a rat model of Angelman Syndrome identified Ube3a-dependent social behaviors, suggesting potential similarities and differences in rodent models.