Journal
TRENDS IN IMMUNOLOGY
Volume 43, Issue 6, Pages 423-425Publisher
CELL PRESS
DOI: 10.1016/j.it.2022.04.004
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Funding
- Career Award for Medical Scientists from the Burroughs Wellcome Fund
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This article discusses the impact of the extracellular matrix (ECM) on antitumor immunity, demonstrating that discoidin domain receptor 1-mediated collagen assembly can exclude T cells from tumors.
Extracellular matrix (ECM) is an integral component of solid cancers; however, the impact of the ECM on antitumor immunity has remained elusive. Sun and colleagues now demonstrate that discoidin domain receptor 1-mediated collagen assembly can exclude T cells from tumors. Together, recent studies highlight ECM as an active regulator of immunity in cancer.
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