Journal
TRENDS IN GENETICS
Volume 38, Issue 7, Pages 646-649Publisher
CELL PRESS
DOI: 10.1016/j.tig.2022.02.011
Keywords
genome stability; faithful chromosome; ATP-independent manner; transcriptional repression
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Funding
- European Com-mission (Marie-Curie Individual Fellowship) [657244, EpiGeneSys HEALTH-2010-2570 82]
- Friedrich-Baur-Stiftung
- DFG [453441129]
- Heisenberg Program of the DFG
- Marie Curie Actions (MSCA) [657244] Funding Source: Marie Curie Actions (MSCA)
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This article discusses new insights into the role and recruitment mechanisms of the multitasking histone chaperone FACT in gene silencing, and its potential implications in cell identity and cancer.
The multitasking histone chaperone FACT (FAcilitates Chromatin Transcription) contributes to actively transcribed euchromatin and repressed heterochromatin. However, its precise role in gene silencing has remained obscure. Here, we discuss new insights into the silent chromatin functions and recruitment mechanisms of FACT, and their possible implications in cell identity and cancer.
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