Catastrophic DNA replication in unscheduled tetraploid cells

Article Multidisciplinary Sciences

Genetic instability from a single S phase after whole-genome duplication

Simon Gemble et al.

Summary: This study reveals that human cells experience high levels of DNA damage during DNA replication in the first S phase following tetraploidy induction. These damages are caused by protein shortage during the G1/S transition, resulting in inaccurate DNA replication. These findings provide an explanation for the genetic instability landscape that favors tumorigenesis after tetraploidization.

NATURE (2022)

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Review Biochemistry & Molecular Biology

Intratumoral heterogeneity in cancer progression and response to immunotherapy

Ilio Vitale et al.

Summary: Tumors evolve under various pressures and exhibit considerable heterogeneity in genetic, phenotypic, and behavioral aspects. This intratumoral heterogeneity influences disease progression and treatment sensitivity, necessitating consideration of multiple levels of heterogeneity in future therapeutic approaches.

NATURE MEDICINE (2021)

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Article Cell Biology