Journal
TRENDS IN GENETICS
Volume 38, Issue 8, Pages 787-788Publisher
CELL PRESS
DOI: 10.1016/j.tig.2022.04.005
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Funding
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [20417]
- Italian Institute for Genomic Medicine and Compagnia di San Paolo
- US Department of Defense Breast Cancer Research Program [BC180476P1, BC210945]
- 2019 Laura Ziskin Prize in Translational Research from the Stand Up to Cancer (SU2C) [ZP-6177]
- Leukemia and Lymphoma Society (LLS)
- Dep of Radiation Oncology at Weill Cornell Medicine
- Functional Genomics Initiative
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Unscheduled tetraploidy, a meta-stable state, quickly develops into aneuploidy. Freshly formed tetraploid cells fail to accumulate necessary DNA replication factors after whole-genome duplication (WGD) during the first G1 phase, resulting in genetic instability and extensive karyotypic alterations during the subsequent S phase.
Unscheduled tetraploidy is a meta-stable state that rapidly evolves into aneuploidy. Recent findings re-ported by Gemble et al. demon-strate that freshly formed tetraploid cells fail to accumulate the required amounts of DNA replication fac-tors during the first G1 phase after whole-genome duplication (WGD), culminating in genetic instability in the subsequent S phase and exten-sive karyotypic alterations.
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