Journal
TRENDS IN BIOTECHNOLOGY
Volume 40, Issue 10, Pages 1148-1159Publisher
CELL PRESS
DOI: 10.1016/j.tibtech.2022.03.004
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Funding
- Novo Nordisk Foundation [NNF20CC0035580, NNF18OC0034818, NNF21OC0067996]
- Danish Council for Independent Research (SWEET, DFF-Research Project) [8021-00039B]
- European Union [814418]
- Cystic Fibrosis Trust
- Strategic Research Centre Award [2019-SRC017]
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This article proposes a 'metabolism-centric' approach to the design-build-test-learn cycle in synthetic biology, supported by multi-omic analyses, to facilitate the deployment of microbial cell factories designed for bioproduction beyond the typical landscape of target products.
Major advances toward a bio-based industry enabled cost-efficient bioproduction of multiple chemicals, yet successful industrial processes are relatively scarce and limited to the use of few workhorse microbes as hosts. An in-depth understand-ing of the physiology and metabolism of nontraditional microorganisms is key to un-leash their biotechnological potential. The inception of biofoundries multiplied the capacity of constructing and testing a large number of microbial strains tailored for bioproduction - and we argue that automation workflows therein can be adapted to gain fundamental knowledge of nontraditional hosts. Here, we propose a 'metabolism-centric' approach to the design-build-test-learn cycle of synthetic biology, supported by multi-omic analyses, to facilitate the deployment of microbial cell factories designed for bioproduction beyond the typical landscape of target products.
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