Related references
Note: Only part of the references are listed.Kincore: a web resource for structural classification of protein kinases and their inhibitors
Vivek Modi et al.
NUCLEIC ACIDS RESEARCH (2022)
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation
Caleb R. Glassman et al.
SCIENCE (2022)
Type II Binders Targeting the GLR-Out Conformation of the Pseudokinase STRADα
Ryan H. B. Smith et al.
BIOCHEMISTRY (2021)
The ABCs of the atypical Fam20 secretory pathway kinases
Carolyn A. Worby et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
Coronavirus replication-transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit
Heiko Slanina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
Dimeric Structure of the Pseudokinase IRAK3 Suggests an Allosteric Mechanism for Negative Regulation
Sven M. Lange et al.
STRUCTURE (2021)
From structure to the dynamic regulation of a molecular switch: A journey over 3 decades
Susan S. Taylor et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis
Sarah E. Garnish et al.
NATURE COMMUNICATIONS (2021)
The intracellular domains of the EphB6 and EphA10 receptor tyrosine pseudokinases function as dynamic signalling hubs
Lung-Yu Liang et al.
BIOCHEMICAL JOURNAL (2021)
Structural and mechanistic basis for protein glutamylation by the kinase fold
Adam Osinski et al.
MOLECULAR CELL (2021)
Choline kinase alpha 2 acts as a protein kinase to promote lipolysis of lipid droplets
Rui Liu et al.
MOLECULAR CELL (2021)
Activation loop phosphorylaton of a non-RD receptor kinase initiates plant innate immune signaling
Kyle W. Bender et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)
There's more to death than life: Noncatalytic functions in kinase and pseudokinase signaling
Peter D. Mace et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2021)
The Ras switch in structural and historical perspective
Raphael Gasper et al.
BIOLOGICAL CHEMISTRY (2020)
High-Resolution Structure and Inhibition of the Schizophrenia Linked Pseudokinase ULK4
Susmita Khamrui et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis
Daqian Xu et al.
NATURE (2020)
Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex
James Chen et al.
CELL (2020)
Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases
Joshua B. Sheetz et al.
MOLECULAR CELL (2020)
Nucleotide Binding, Evolutionary Insights, and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4
Franziska Preuss et al.
STRUCTURE (2020)
Moonlighting functions of metabolic enzymes and metabolites in cancer
Chaoyun Pan et al.
MOLECULAR CELL (2020)
The pseudokinase domains of guanylyl cyclase-A and -B allosterically increase the affinity of their catalytic domains for substrate
Aaron B. Edmund et al.
SCIENCE SIGNALING (2019)
Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases
Miles H. Black et al.
SCIENCE (2019)
Tracing the origin and evolution of pseudokinases across the tree of life
Annie Kwon et al.
SCIENCE SIGNALING (2019)
Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165
Stephen T. Wrobleski et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Inhibition of bacterial ubiquitin ligases by SidJ-calmodulin catalysed glutamylation
Sagar Bhogaraju et al.
NATURE (2019)
Glutamylation of Bacterial Ubiquitin Ligases by a Legionella Pseudokinase
Alan G. Sulpizio et al.
TRENDS IN MICROBIOLOGY (2019)
The crystal structure of pseudokinase PEAK1 (Sugen kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization
Byung Hak Ha et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis
Emma J. Petrie et al.
NATURE COMMUNICATIONS (2018)
Protein AMPylation by an Evolutionarily Conserved Pseudokinase
Anju Sreelatha et al.
CELL (2018)
Phase 2 Trial of Selective Tyrosine Kinase 2 Inhibition in Psoriasis
Kim Papp et al.
NEW ENGLAND JOURNAL OF MEDICINE (2018)
Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1
Sam A. Jamieson et al.
SCIENCE SIGNALING (2018)
Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells
Daniel M. Foulkes et al.
SCIENCE SIGNALING (2018)
Flipping ATP to AMPlify Kinase Functions
Joshua B. Sheetz et al.
CELL (2018)
Enzymes Involved in AMPylation and deAMPylation
Amanda K. Casey et al.
CHEMICAL REVIEWS (2018)
3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy
Masamichi Nagae et al.
GENES TO CELLS (2017)
Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease
Patrick A. Eyers et al.
TRENDS IN CELL BIOLOGY (2017)
Structure of Fam20A reveals a pseudokinase featuring a unique disulfide pattern and inverted ATP-binding
Jixin Cui et al.
ELIFE (2017)
Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling
Neil S. Dhawan et al.
NATURE (2016)
Overcoming resistance to HER2 inhibitors through state-specific kinase binding
Chris J. Novotny et al.
NATURE CHEMICAL BIOLOGY (2016)
Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors
Mark W. Richards et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Structural Basis for the Non-catalytic Functions of Protein Kinases
Jennifer E. Kung et al.
STRUCTURE (2016)
Structure of protein O-mannose kinase reveals a unique active site architecture
Qinyu Zhu et al.
ELIFE (2016)
The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner
Fiona P. Bailey et al.
BIOCHEMICAL JOURNAL (2015)
Lack of Evidence for PKM2 Protein Kinase Activity
Aaron M. Hosios et al.
MOLECULAR CELL (2015)
ATP binding to the pseudokinase domain of JAK2 is critical for pathogenic activation
Henrik M. Hammaren et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD
Susan K. Fetics et al.
STRUCTURE (2015)
Molecular Mechanism of CCAAT-Enhancer Binding Protein Recruitment by the TRIB1 Pseudokinase
James M. Murphy et al.
STRUCTURE (2015)
A Secretory Kinase Complex Regulates Extracellular Protein Phosphorylation
Jixin Cui et al.
ELIFE (2015)
PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
Peter V. Hornbeck et al.
NUCLEIC ACIDS RESEARCH (2015)
Insights into the evolution of divergent nucleotide-binding mechanisms among pseudokinases revealed by crystal structures of human and mouse MLKL
James M. Murphy et al.
BIOCHEMICAL JOURNAL (2014)
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
James M. Murphy et al.
BIOCHEMICAL JOURNAL (2014)
Drugging MYCN through an Allosteric Transition in Aurora Kinase A
William Clay Gustafson et al.
CANCER CELL (2014)
The Leucine-Rich Repeat Receptor Kinase BIR2 Is a Negative Regulator of BAK1 in Plant Immunity
Thierry Halter et al.
CURRENT BIOLOGY (2014)
Structural insights into regulatory mechanisms of MO25-mediated kinase activation
Qian Hao et al.
JOURNAL OF STRUCTURAL BIOLOGY (2014)
Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase
Yibing Shan et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2014)
Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition
Patrick J. Lupardus et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis
Jianzhong Wen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations
Peter Littlefield et al.
SCIENCE SIGNALING (2014)
Day of the dead: pseudokinases and pseudophosphatases in physiology and disease
Veronika Reiterer et al.
TRENDS IN CELL BIOLOGY (2014)
A pickup in pseudokinase activity
Arvin C. Dar
BIOCHEMICAL SOCIETY TRANSACTIONS (2013)
Oncogenic ERBB3 Mutations in Human Cancers
Bijay S. Jaiswal et al.
CANCER CELL (2013)
The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
James M. Murphy et al.
IMMUNITY (2013)
Structural Characterization of the RLCK Family Member BSK8: A Pseudokinase with an Unprecedented Architecture
Christian Gruetter et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases
Angela V. Toms et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2013)
Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor
S. Yoshikawa et al.
ONCOGENE (2013)
SGK196 Is a Glycosylation-Specific O-Mannose Kinase Required for Dystroglycan Function
Takako Yoshida-Moriguchi et al.
SCIENCE (2013)
Structure of the MST4 in Complex with MO25 Provides Insights into Its Activation Mechanism
Zhubing Shi et al.
STRUCTURE (2013)
The Insulin Receptor: Both a Prototypical and Atypical Receptor Tyrosine Kinase
Stevan R. Hubbard
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family
Stephen C. Artim et al.
BIOCHEMICAL JOURNAL (2012)
Interactions with WNK (With No Lysine) Family Members Regulate Oxidative Stress Response 1 and Ion Co-transporter Activity
Samarpita Sengupta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Role of N-Terminal Myristylation in the Structure and Regulation of cAMP-Dependent Protein Kinase
Adam C. Bastidas et al.
JOURNAL OF MOLECULAR BIOLOGY (2012)
Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F
Rajintha M. Bandaranayake et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
A Conserved Non-canonical Motif in the Pseudoactive Site of the ROP5 Pseudokinase Domain Mediates Its Effect on Toxoplasma Virulence
Michael L. Reese et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms
Natalia Jura et al.
MOLECULAR CELL (2011)
A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK
Damian F. Brennan et al.
NATURE (2011)
The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling
Daniela Ungureanu et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)
Pseudokinases-remnants of evolution or key allosteric regulators?
Elton Zeqiraj et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2010)
Structural Comparison of Human Mammalian Ste20-Like Kinases
Christopher J. Record et al.
PLOS ONE (2010)
ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation
Fumin Shi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region
Toshiyasu Koike et al.
BIOCHEMICAL JOURNAL (2009)
Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma
Tobias Otto et al.
CANCER CELL (2009)
Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii
Wei Qiu et al.
EMBO JOURNAL (2009)
The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions
Koichi Fukuda et al.
MOLECULAR CELL (2009)
Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3
Natalia Jura et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation
Elton Zeqiraj et al.
SCIENCE (2009)
ATP and MO25 alpha Regulate the Conformational State of the STRAD alpha Pseudokinase and Activation of the LKB1 Tumour Suppressor
Elton Zeqiraj et al.
PLOS BIOLOGY (2009)
CASK functions as a Mg2+-independent neurexin kinase
Konark Mukherjee et al.
CELL (2008)
Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II
Benjamin Stieglitz et al.
EMBO JOURNAL (2008)
An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
Xuewu Zhang et al.
CELL (2006)
A Src-like inactive conformation in the Abl tyrosine kinase domain
Nicholas M. Levinson et al.
PLOS BIOLOGY (2006)
Structural and mechanistic insights into ras association domains of phospholipase C epsilon
TD Bunney et al.
MOLECULAR CELL (2006)
Emerging roles of pseudokinases
Jerome Boudeau et al.
TRENDS IN CELL BIOLOGY (2006)
Plant and animal pathogen recognition receptors signal through non-RD kinases
Christopher Dardick et al.
PLOS PATHOGENS (2006)
Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders
AV Jones et al.
BLOOD (2005)
Protein kinase inhibitors: Insights into drug design from structure
MEM Noble et al.
SCIENCE (2004)
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
PTC Wan et al.
CELL (2004)
Regulation of protein kinases: Controlling activity through activation segment conformation
B Nolen et al.
MOLECULAR CELL (2004)
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension
XS Min et al.
STRUCTURE (2004)
The protein kinase complement of the human genome
G Manning et al.
SCIENCE (2002)
Structures of the cancer-related aurora-A, FAK, and EphA2 protein kinases from nanovolume crystallography
J Nowakowski et al.
STRUCTURE (2002)
Human hypertension caused by mutations in WNK kinases
FH Wilson et al.
SCIENCE (2001)
Kinetic and catalytic mechanisms of protein kinases
JA Adams
CHEMICAL REVIEWS (2001)
Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ
ME Pacold et al.
CELL (2000)
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II
BE Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Share Paper
