A 'NAC' for targeting proteins to the ER

The signal recognition particle (SRP) cotranslationally targets a large and diverse portion of the nascent proteome to the endoplasmic reticulum (ER). A recent study by Jomaa et al. reveals an unexpected function for the ribosome-bound nascent chain-associated complex (NAC) in sensing ER-targeting signals and recruiting SRP to the appropriate ribosomes for high-fidelity targeting.

Automated summary

A recent study reveals an unexpected role of ribosome-bound nascent chain-associated complex in sensing ER-targeting signals and recruiting SRP for accurate protein targeting.