Journal
CANCER INVESTIGATION
Volume 33, Issue 5, Pages 165-171Publisher
INFORMA HEALTHCARE
DOI: 10.3109/07357907.2015.1019676
Keywords
Lung Cancer; H1299; cancer stem cell; Radioresistance; miRNA
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This study demonstrated that miR-21 and miR-95 expression were significantly higher in the ALDH1(+)CD133(+)subpopulation than in the ALDH1(--)CD133(--)subpopulation of lung cancer cells. Combined delivery of anti-miR-21 and anti-miR-95 by calcium phosphate nanoparticles significantly inhibited tumor growth in a xenograft tumor model and sensitized radiotherapy. The anti-miRNAs significantly reduced miR-21 and miR-95 levels, increased PTEN, SNX1, and SGPP1 protein expression, but reduced Akt Ser(473) and Thr(308) phosphorylation. ALDH1(+)CD133(+)subpopulation of NSCLC tumor cells confers radioresistance due to high expression of miR-21 andmiR-95. Targeting inhibition of miR-21 andmiR-95 can inhibit tumor growth through elevating PTEN, SNX1, and SGPP1 expression and inhibiting Akt phosphorylation.
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