Journal
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE
Volume 116, Issue 12, Pages 1226-1229Publisher
OXFORD UNIV PRESS
DOI: 10.1093/trstmh/trac033
Keywords
aggregation; schistosomiasis; soil-transmitted helminths
Funding
- Bill and Melinda Gates Foundation [OPP1184344]
- NTD Modelling Consortium
- Bill and Melinda Gates Foundation [OPP1184344] Funding Source: Bill and Melinda Gates Foundation
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The study found that soil-transmitted helminths and schistosome parasites are highly aggregated within the human population. Statistical methods were used to estimate the aggregation parameter k using two large independent datasets. The results of the study suggest that greater attention needs to be given to identifying and treating remaining aggregates of parasites.
Background Soil-transmitted helminths (STH) and schistosome parasites are highly aggregated within the human population. The probability distribution of worms per person is described well by the negative binomial probability distribution with aggregation parameter, k, which varies inversely with parasite clustering. The relationship between k and prevalence in defined populations subject to mass drug administration is not well understood. Methods and Results We use statistical methods to estimate k using two large independent datasets for STH and schistosome infections from India and Niger, respectively, both of which demonstrate increased aggregation of parasites in a few hosts, as the prevalence of infections declines across the dataset. Conclusions A greater attention needs to be given in monitoring and evaluation programmes to find and treat the remaining aggregates of parasites.
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