4.5 Article

Evaluation of Variability Across Rat Acute Oral Systemic Toxicity Studies

Related references

Note: Only part of the references are listed.
Article Medicine, Legal

A cross-industry collaboration to assess if acute oral toxicity (Q)SAR models are fit-for-purpose for GHS classification and labelling

Joel Bercu et al.

Summary: This study evaluated the accuracy and applicability of AOT in silico models provided by Leadscope software, demonstrating their reliability across different industrial sectors. Additionally, the importance of expert review and guidance on using these models to meet testing requirements, GHS classification/labelling, and transportation needs was emphasized.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2021)

Article Medicine, Legal

Analysis of variability in the rabbit skin irritation assay

John P. Rooney et al.

Summary: The study established a curated data set of 2624 test records to assess the reproducibility of the in vivo rabbit test, revealing the greatest variability between moderate and mild irritants. Increased reproducibility was observed when using a binary categorization between corrosives/moderate irritants and mild/nonirritants.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2021)

Article Environmental Sciences

CATMoS: Collaborative Acute Toxicity Modeling Suite

Kamel Mansouri et al.

Summary: The international collaboration in developing in silico models for predicting acute oral toxicity, resulting in the CATMoS, has demonstrated high performance in terms of accuracy and robustness. This modeling suite is being evaluated by regulatory agencies as a potential replacement for in vivo rat acute oral toxicity studies.

ENVIRONMENTAL HEALTH PERSPECTIVES (2021)

Review Public, Environmental & Occupational Health

A Review of the LD50 and Its Current Role in Hazard Communication

Keith Morris-Schaffer et al.

Summary: This paper aims to review the LD50, its history, current research used to develop it, and its role in hazard communication. One of the primary drivers of change for the LD50 and its regulatory integration has been continual improvement in animal welfare and reduction in animal costs. Ongoing regulatory adoption of The Globally Harmonized System of Classification and Labeling of Chemicals (GHS) has integrated LD50 data into a common hazard communication language, allowing for consistent hazard communication without requiring new animal testing.

ACS CHEMICAL HEALTH & SAFETY (2021)

Article Computer Science, Information Systems

Extension of pQSAR: Ensemble Model Generated by Random Forest and Partial Least Squares Regressions

Byung Chun Kim et al.

IEEE ACCESS (2020)

Article Chemistry, Multidisciplinary

Consensus models to predict oral rat acute toxicity and validation on a dataset coming from the industrial context

F. Lunghini et al.

SAR AND QSAR IN ENVIRONMENTAL RESEARCH (2019)

Article Medicine, Legal

Status of acute systemic toxicity testing requirements and data uses by US regulatory agencies

Judy Strickland et al.

REGULATORY TOXICOLOGY AND PHARMACOLOGY (2018)

Article Chemistry, Multidisciplinary

OPERA models for predicting physicochemical properties and environmental fate endpoints

Kamel Mansouri et al.

JOURNAL OF CHEMINFORMATICS (2018)

Article Chemistry, Multidisciplinary

The CompTox Chemistry Dashboard: a community data resource for environmental chemistry

Antony J. Williams et al.

JOURNAL OF CHEMINFORMATICS (2017)

Article Chemistry, Multidisciplinary

An automated curation procedure for addressing chemical errors and inconsistencies in public datasets used in QSAR modelling

K. Mansouri et al.

SAR AND QSAR IN ENVIRONMENTAL RESEARCH (2016)

Article Psychology, Social

Detecting outliers: Do not use standard deviation around the mean, use absolute deviation around the median

Christophe Leys et al.

JOURNAL OF EXPERIMENTAL SOCIAL PSYCHOLOGY (2013)

Article Veterinary Sciences

Analysis of environmental sound levels in modern rodent housing rooms

Amanda M. Lauer et al.

LAB ANIMAL (2009)

Article Toxicology

Acutoxbase, an innovative database for in vitro acute toxicity studies

Agnieszka Kinsner-Ovaskainen et al.

TOXICOLOGY IN VITRO (2009)