Fast and Unique Electrochemical Sensor Amplified with MgO/CNTs and Ionic Liquid for Monitoring of Isuprel in Pharmaceutical and Biological Fluid Samples

The purpose of this study was to investigate the electrochemical sensing of isuprel in biological fluids and pharmaceutical samples using a modified paste electrode (MPE). PE was amplified and used as a new analytical tool for Isuprel monitoring using a MgO/CNTs nanocomposite and 1-butyl-3-methylimidazolium hexafluorophosphate (BMHFP). In an aqueous solution, the MgO/CNTs/BMHFP/MPE system increased the oxidation signal of Isuprel by approximately 4.15 times. Under optimal analytical conditions (pH = 7.0), the oxidation signal of Isuprel was reduced by approximately 145 mV at the surface of MgO/CNTs/BMHFP/MPE in comparison to MPE, confirming the mediators' catalytic activity at the surface sensor. The MgO/CNTs/BMHFP/MPE monitored Isuprel in the concentration range 0.6 nM-420 mu M with a detection limit of 0.1 nM, respectively. The ability of MgO/CNTs/BMHFP/MPE to monitor Isuprel in injection and dextrose saline samples was demonstrated using standard addition data.

Automated summary

This study successfully investigated the electrochemical sensing of isuprel in biological fluids and pharmaceutical samples using a modified paste electrode. The use of MgO/CNTs nanocomposite and BMHFP as mediators showed promising results in amplifying the oxidation signal of isuprel at the surface of the electrode, enabling reliable monitoring of isuprel concentration with a low detection limit.