Journal
CANCER INVESTIGATION
Volume 33, Issue 9, Pages 429-439Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2015.1060996
Keywords
Claudin 1; Breast cancer; Tamoxifen; Migration; MCF7; Estrogen; TGF beta
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Funding
- Canadian Breast Cancer Foundation (CBCF) Prairie
- Manitoba Health Research Council (MHRC)
- CancerCare Manitoba
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Downregulation of claudin 1, a critical tight junction protein, has been correlated with increased invasiveness in breast cancer. However, recent studies suggest that claudin 1 contributes to the progression of some molecular subtypes of breast cancer. In this study, claudin 1 promotes migration in luminal-like MCF7 human breast cancer cells and increases their sensitivity to tamoxifen, etoposide, and cisplatin. We also observed an inverse relationship between upregulation of claudin 1 and TGF beta. Collectively, our results suggest that claudin 1 has the potential to be used as a predictive marker for treatment efficacy for specific breast cancer patient subgroups.
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