Journal
CANCER INVESTIGATION
Volume 33, Issue 9, Pages 469-475Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2015.1069831
Keywords
Endometrial cancer; Fli-1; Tumor grade; Prognostic factor
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Funding
- Ministry of Education Key Project of Science and Technology [311015]
- Chinese Ministry of Science and Technology [2012CB911100]
- National Natural Science Foundation of China for young scholars [30901702]
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This study aimed to investigate the expression of Friend leukemia virus integration 1 (Fli-1) and its correlation with the prognosis of endometrial cancer (EC). Thirty-two EC tissue samples were evaluated for Fli-1 expression using immunohistochemistry. Fli-1 showed significantly high expression in EC cells, followed by hyperplasia cells, and was negative in adjacent normal tissues. The high expression of Fli-1 was significantly associated with a high differentiation grade, mutated P53 expression, and histological subtype (p<.05). Downregulation of Fli-1 in AN3CN cells using RNA interference inhibited cell clone formation and proliferation but did not affect apoptosis and migration of the cells. This study provides the first evidence that Fli-1 expression gradually increases in parallel with disease progression, and its overexpression might predict poor prognosis in EC.
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