The effect of Iodixanol on the thermodynamic properties of blood components

The effects of Iodixanol contrast medium were studied on human blood samples with differential scanning calorimetry (DSC). Measurements on anticoagulated and non-anticoagulated samples revealed that the components of the plasma and serum turned into a thermodynamically less stable state in the presence of Iodixanol. The thermal parameters of the main transition peak changed in the same way for both the plasma and serum erythrocyte samples in the presence of Iodixanol. The T-max1 values of the main thermal transition were not dramatically different (similar to 70 degrees C). The T-max2 value of the peak at higher temperature range (similar to 80-85 degrees C) shifted considerably (by 3.97-4.89 degrees C) towards the lower temperature range, while the Delta H value showed a significant drop (similar to 61%) in the presence of higher concentration of Iodixanol. The results suggest that Iodixanol in blood samples can induce specific changes in the structure of blood components by altering the fundamental thermodynamic properties of the underlying biological system.

Automated summary

This study investigated the effects of Iodixanol contrast medium on human blood samples using differential scanning calorimetry (DSC). The results showed that the presence of Iodixanol caused thermodynamic instability in the plasma and serum components, leading to specific changes in the structure of blood components.