Journal
TETRAHEDRON LETTERS
Volume 99, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2022.153833
Keywords
Salen; Cobalt; Fluorous; Henry reaction
Categories
Funding
- JSPS KAKENHI [JP22K05469]
- Takahashi Industrial and Economic Research Foundation [11-003-020]
- Ichihara International Scholarship Foundation (29th Research Grant)
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A highly stereoselective asymmetric Henry reaction was achieved using a double fluorous-tagged Co-salen complex, which showed improved stereoselectivity compared to introducing a nitro group in the same position of the salen ligand. The observed stereoselectivity was significantly higher than that of a Jacobsen-type Co-salen complex with the same asymmetric source.
A highly stereoselective asymmetric Henry reaction using a double fluorous-tagged Co-salen complex was conducted. The introduction of two fluorous tags into the Co-salen complex was found to be more effective in terms of improving stereoselectivity than the introduction of a strong electron-withdrawing nitro group into the same position of the salen ligand. The observed stereoselectivity was significantly higher than that when using a Jacobsen-type Co-salen complex bearing the same asymmetric source. (c) 2022 Elsevier Ltd. All rights reserved.
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