An efficient, cyanide free total synthesis of rosuvastatin calcium

A simple, efficient, cyanide-free protocol for the total synthesis of rosuvastatin calcium was developed from inexpensive, commercially available D-arabinose; the key steps employed were Wittig reaction followed by oxa-Michael addition. The developed synthetic protocol could be adopted for industrial production of rosuvastatin calcium. (C)& nbsp;2022 Elsevier Ltd. All rights reserved.

Automated summary

A simple and efficient cyanide-free protocol for the total synthesis of rosuvastatin calcium was developed using inexpensive and commercially available D-arabinose as the starting material. The key steps involved Wittig reaction followed by oxa-Michael addition. This synthetic protocol can be applied for industrial production of rosuvastatin calcium.