Journal
TALANTA
Volume 239, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2021.123111
Keywords
Cytochrome P450; Fluorescence imaging; Chemotherapy; Liver cancer
Categories
Funding
- National Nature Science Foundation of China [21804010, 21976209, 22007005]
- science and technology innovation development plan of Yantai of China [2020MSGY113, 2020YT06000898]
- Research Initiation Fund of Binzhou Medical University [BY2019KYQD39, BY2020KYQD01]
- Taishan Scholar Project Special Funding [ts20190962]
- Shandong Peninsula Engineering Research Center of Comprehensive Brine Utilization [2018LS014]
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Cancer drug resistance is a major factor in treatment failure, with CYP450 playing a crucial role in its development. Monitoring CYP450 levels can assess tumor cell responses to drugs and improve treatment outcomes. The synergistic effect of 1-ABT and cisplatin may have superior results in cancer therapy.
Cancer is a complex disease with very high incidence and mortality rates every year. However, cancer drug resistance greatly mitigates the cure rates of tumors, and cytochrome P450 (CYP450) plays an important role in the development of cisplatin resistance. We developed the aggregation-induced emission luminogen (AIEgen) TPE-CYP to monitor the changes in CYP450. The TPE-CYP fluorescent probe was successfully used to assess CYP450 levels in tumor cells and tumor tissue sections. This study presented that CYP450 level in HepG2/DDP cells (cisplatin-resistant cells) was higher than that in HepG2 cells, and the inhibition of CYP450 by 1-ABT effectively improved the tumor resistance. Thus, CYP450 plays a key role in the development of tumor resistance. The synergistic effect of 1-ABT and the chemotherapeutic agent cisplatin was superior to that of cisplatin alone in tumor-bearing mice. The TPE-CYP probe will provide an idea for the clinical implementation of individualized tumor treatment strategies, through the accurate monitoring of CYP450.
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