One-pot multicomponent synthesis approach for tetrahydropyridines using polyaniline-zirconium oxide composites

Tetrahydropyridines, one-pot five-component green synthesis from aldehydes, anilines, and beta-keto esters by cyclo-condensation using polyaniline-zirconium oxide catalyst. It is an efficient protocol due to the simplicity in reaction conditions, simple catalyst generation, and excellent product yield. The catalyst can be effortlessly recovered from the reaction mixture and reused up to the seven catalytic cycles without losing substantial catalytic activity. The present protocol offers prominent advantages over other reaction conditions in terms of a simple workup procedure, exceptional atomic economy, affordability, and wide substrate scope.

Automated summary

This study presents a green synthesis method for the one-pot five-component synthesis of tetrahydropyridines using a polyaniline-zirconium oxide catalyst. The catalyst exhibits excellent catalytic activity and can be easily recovered and reused up to seven cycles. The method offers significant advantages in terms of simplicity, affordability, and wide substrate scope.