Journal
SYNTHESIS-STUTTGART
Volume 54, Issue 22, Pages 5042-5054Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1827-2987
Keywords
aryne; ene reaction; arylation; arene functionalization
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Funding
- EPSRC [EP/M026221/1]
- China Scholarship Council
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Intermolecular aryne ene reactions provide opportunities for arylation of various unsaturated substrates in a single step, while intramolecular reactions offer expedient access to valuable benzo-fused carbo- and heterocyclic frameworks. This review charts the development of the aryne ene reaction, from initial reports explaining unexpected byproduct formation in competing [4+2] and [2+2] cycloadditions to its application in contemporary synthetic methodology.
Intermolecular aryne ene reactions present opportunities to arylate a wide range of unsaturated substrates in a single step, whilst intramolecular reactions provide expedient access to valuable benzo-fused carbo- and heterocyclic frameworks. This short review will chart the development of the aryne ene reaction from initial reports that rationalise unexpected byproduct formation in competing [4+2] and [2+2] cycloadditions through to its exploitation in contemporary synthetic methodology.
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