4.4 Article

Palladium-Catalyzed Synthesis of Heterocyclic Ring Systems by Combination of Regioselective C-C with Twofold C-N Couplings

Journal

SYNLETT
Volume 33, Issue 13, Pages 1215-1226

Publisher

GEORG THIEME VERLAG KG
DOI: 10.1055/s-0040-1719918

Keywords

catalysis; cross-coupling; heterocycles; palladium; regioselectivity

Ask authors/readers for more resources

The combination of regioselective palladium-catalyzed C-C with twofold C-N couplings allows for the synthesis of a variety of heterocyclic ring systems, including complex polyheterocyclic systems, which are of pharmacological relevance or interesting in the field of material science.
The combination of regioselective palladium-catalyzed C-C with twofold C-N couplings allows for the synthesis of a variety of heterocyclic ring systems. Starting materials include thiophenes arid benzothiophenes, pyrroles and indoles, furans and benzofurans, pyridines, quinolines and quinoxalines, complex heterocyclic systems and benzophenone derivatives. The products are in many cases complex polyheterocyclic systems, which are not readily available by other methods or, in a number of cases, were not described in the literature before. They are of pharmacological relevance or interesting in the field of material science. Products include thieno[3,2-b:4,5-b']diindoles, thieno[3,2-b]indoles, thieno[3,4-b]indoles, 5,10-dihydroindolo[3,2-b]indoles, furo[3,2-b:4,5-b']diindoles, benzo[4,5]furo[3,2-b]indoles, 5,7-dihydropyrido[3,2-b:5,6-b']diindoles, 5,7-dihydropyrido[2,3-b:6,5-b']diindotes, alpha- , beta-, gamma- and delta-carbolines, indolo[3,2-b]quinolines, indolo[2,3-b]quinolines, indolo[3,2-c]quinolines, indoloquinoxalines, pyrido[2',1':2,3]imidazo[4,5-b]indoles, thiadiazolo[2',3':2,3]imidazo[4,5-Nindoles, benzo[b]carbazolediones, acridones and thieno[3,2-b]quinolones.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available