Journal
SYNLETT
Volume 33, Issue 13, Pages 1287-1289Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0041-1738371
Keywords
Trost ligand; DACH-Ph; coupling; 2-diphenylphosphinyl-benzoic acid; chiral diaminocyclohexane; CDI; imidazole hydrochloride; kilogram
Categories
Ask authors/readers for more resources
An improved chemical process for the synthesis of (S,S)-DACH-Ph Trost ligand has been developed. The process is simple and high-yielding, and purification can be achieved without the need for column chromatography.
An improved chemical process has been developed for the synthesis of (S,S)-DACH-Ph Trost ligand. The amidation of 2-diphenylphosphinylbenzoic acid and (S,S)-diaminocyclohexarie is promoted by stoichiometric CDI and catalytic imidazole hydrochloride. The resulting product, (S,S)-DACH-Ph Trost ligand, is isolated as a white solid in 80% yield with >99% ee by simple filtration without column chromatography. The current facile process is also demonstrated on kilogram scale.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available