Polyoxometalate-Ionic Liquid-Catalyzed Ritter Reaction for Efficient Synthesis of Amides

A series of polyoxometalate-ionic liquid catalysts that combine the features of a polyoxometalate and an ionic liquid, with the introduction of acidity and miscibility, have been developed to promote the Ritter reaction. Among them, [BSmim]CuPW12O40 [BSmim = 1-methyl-3-(4-sulfobutyl)-1H-imidazol-3-ium] displayed the highest activity for the amidation of a variety of alcohols with nitrites, delivering the corresponding amide products in good to excellent yields. Furthermore, the reaction can be easily scaled up to a gram scale without losing efficiency. This process therefore provides an appealing way to prepare amides by a Ritter reaction using a polyoxometalate-ionic liquid-based catalyst.

Automated summary

A series of polyoxometalate-ionic liquid catalysts have been developed to promote the Ritter reaction by introducing acidity and miscibility. Among them, [BSmim]CuPW12O40 [BSmim = 1-methyl-3-(4-sulfobutyl)-1H-imidazol-3-ium] displayed the highest activity for the amidation of alcohols with nitrites, delivering the corresponding amide products in good to excellent yields. Furthermore, the reaction can be easily scaled up to a gram scale without losing efficiency.