Cartwheels create symmetry and asymmetry

In this issue of Structure, Kantsadi et al. (2022) present the crystal structures of coiled-coil bundles from SAS-6, a core component of the centriole cartwheel, and reveal that two coiled-coil domains interact asymmetrically. This work provides insights into how the polarity of centrioles is established.

Automated summary

This study presents the crystal structures of coiled-coil bundles from SAS-6 and reveals the asymmetric interaction between two coiled-coil domains, providing new insights into the establishment of centriole polarity.