4.7 Article

Sex-Specific Immune Responses in Stroke

Related references

Note: Only part of the references are listed.
Article Cell Biology

Identification of the key genes and immune infiltrating cells determined by sex differences in ischaemic stroke through co-expression network module

Haipeng Xu et al.

Summary: The study compared differential genes and weighted gene co-expression network analysis in male and female ischemic stroke patients, identifying potential gender-related mechanisms and promising gene targets for sex differences in ischemic stroke. The results also suggested T cells CD8 and Monocytes as potential targets for treatment in male and female patients, respectively.

IET SYSTEMS BIOLOGY (2022)

Article Immunology

Normality sensing licenses local T cells for innate-like tissue surveillance

Duncan R. McKenzie et al.

Summary: This study demonstrates that the sustained interactions between keratinocytes and intraepidermal γδT cells are crucial for maintaining the homeostatic barrier function and phenotype of the γδT cells. These interactions also enable the γδT cells to respond rapidly to tissue perturbation.

NATURE IMMUNOLOGY (2022)

Review Clinical Neurology

Systematic Review of Sex Differences in Ischemic Strokes Among Young Adults: Are Young Women Disproportionately at Risk?

Michelle H. Leppert et al.

Summary: This article aims to reconcile and synthesize existing evidence of sex differences in young adults with ischemic strokes. The results indicate that women have a higher risk of ischemic strokes than men among young adults under the age of 35, while the sex difference is not significant among young adults aged 35-45.

STROKE (2022)

Review Cell Biology

Interconnections between Inflammageing and Immunosenescence during Ageing

Thibault Teissier et al.

Summary: Acute inflammation is necessary for healing, but chronic inflammation is harmful. Inflammageing refers to age-associated chronic inflammation, which is not solely caused by chronological age, but also by biological ageing and increased mortality risk. Cellular senescence and immunosenescence are also involved in inflammageing. This review explores the sources and consequences of inflammageing, focusing on the contribution of cellular senescence and alterations in the ageing immune system. It also discusses potential interventions to reduce inflammageing and improve later life health.

CELLS (2022)

Review Immunology

Interleukin-17 and ischaemic stroke

Qiaohui Zhang et al.

Summary: The IL-17 family plays a crucial role in ischemic stroke, promoting inflammatory response and inducing secondary injury, exacerbating the disease progression.

IMMUNOLOGY (2021)

Article Immunology

X chromosome escapee genes are involved in ischemic sexual dimorphism through epigenetic modification of inflammatory signals

Shaohua Qi et al.

Summary: This study demonstrates that the X escapee genes kdm5c and kdm6a play critical roles in mediating stroke sensitivity, showing significant sex differences in aged WT mice and human stroke patients. The interaction between KDM-Histone-IRF pathways and epigenetic modification of stroke-related genes suggests an important mechanism underlying ischemic sexual dimorphism.

JOURNAL OF NEUROINFLAMMATION (2021)

Editorial Material Clinical Neurology

Under-Enrollment of Women in Stroke Clinical Trials What Are the Causes and What Should Be Done About It?

Cheryl Carcel et al.

Summary: The under-representation of women in clinical trials is a recognized issue that can affect the generalizability of trial outcomes and the utilization of new therapies, with causes including specific trial eligibility criteria, patient attitudes, and potential biases among study personnel. More efforts are needed to address this problem, such as using trial screening logs, conducting qualitative studies to understand patient attitudes, avoiding age-based exclusion criteria, and increasing female leadership in stroke clinical trials.

STROKE (2021)

Review Immunology

DAMPs and Innate Immune Training

Elisa Jentho et al.

Summary: The ability to remember previous encounters with pathogens was considered a key feature of the adaptive immune system for a long time, but recent evidence shows that the innate immune system also possesses memory features. This memory is mediated by reorganization of chromatin landscape and adaptations of myelopoiesis. Damage-associated molecular patterns can also induce innate immune memory, potentially through the same receptors and pathways responsible for pathogen-associated innate immune training.

FRONTIERS IN IMMUNOLOGY (2021)

Review Immunology

Uncovering sex differences of rodent microglia

Jinming Han et al.

Summary: There are inherent structural and functional differences in the central nervous systems of females and males, including sex-specific differences in genetic, epigenetic, and hormonal factors. Microglia, as principal resident macrophages in the CNS, have recently been found to exhibit sex-dependent structural and functional differences, which has implications for the design of sex- and microglia-specific therapeutic approaches for CNS diseases.

JOURNAL OF NEUROINFLAMMATION (2021)

Review Immunology

Stroke-induced immunosuppression: implications for the prevention and prediction of post-stroke infections

Julia Faura et al.

Summary: Stroke-induced immunosuppression increases the risk of stroke-associated infections in stroke patients, particularly stroke-associated pneumonia, but there are currently no accurate biomarkers for early diagnosis and prevention. Efforts are being made to explore local immunomodulation as a potential approach for preventive therapy of stroke-associated pneumonia.

JOURNAL OF NEUROINFLAMMATION (2021)

Editorial Material Multidisciplinary Sciences

The importance of sex

Emily Sohn

NATURE (2021)

Review Engineering, Biomedical

Sex differences in the blood-brain barrier and neurodegenerative diseases

Callie M. Weber et al.

Summary: The number of people diagnosed with neurodegenerative diseases is increasing, and there are clear sexual dimorphisms in diseases like Alzheimer's and Parkinson's. While sex as a biological variable is now included in animal studies, it is rarely considered in in vitro models. Sex and sex hormones may affect BBB integrity, with potential mechanisms explained in this review. Current in vitro BBB bioengineered models show promise in studying sex differences in neurodegenerative diseases.

APL BIOENGINEERING (2021)

Article Cell Biology

Aging exacerbates neutrophil pathogenicity in ischemic stroke

Meaghan A. Roy-O'Reilly et al.

AGING-US (2020)

Article Biochemistry & Molecular Biology

Complex sex and estrous cycle differences in spontaneous transient adenosine

Jason R. Borgus et al.

JOURNAL OF NEUROCHEMISTRY (2020)

Article Multidisciplinary Sciences

B cells migrate into remote brain areas and support neurogenesis and functional recovery after focal stroke in mice

Sterling B. Ortega et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Sexual-dimorphism in human immune system aging

Eladio J. Marquez et al.

NATURE COMMUNICATIONS (2020)

Article Cardiac & Cardiovascular Systems

Gut Microbiota-Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice

Juneyoung Lee et al.

CIRCULATION RESEARCH (2020)

Review Immunology

Adaptive Immunity Regulation and Cerebral Ischemia

Xingping Qin et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Immunology

Interleukin-17 in Chronic Inflammatory Neurological Diseases

Jelena Milovanovic et al.

FRONTIERS IN IMMUNOLOGY (2020)

Review Cardiac & Cardiovascular Systems

Toll-Like Receptors Contribute to Sex Differences in Blood Pressure Regulation

Vanessa Dela Justina et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2020)

Article Geriatrics & Gerontology

Role of B cells and the aging brain in stroke recovery and treatment

E. B. Engler-Chiurazz et al.

GEROSCIENCE (2020)

Article Multidisciplinary Sciences

Sex differences in neutrophil biology modulate to I interferons and immunometabolism

Sarthak Gupta et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biochemistry & Molecular Biology

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Nathalie Percie du Sert et al.

PLOS BIOLOGY (2020)

Article Medicine, General & Internal

Sex and gender: modifiers of health, disease, and medicine

Franck Mauvais-Jarvis et al.

LANCET (2020)

Article Immunology

Meningeal γδ T cells regulate anxiety-like behavior via IL-17a signaling in neurons

Kalil Alves de Lima et al.

NATURE IMMUNOLOGY (2020)

Review Immunology

The Role of Gamma-Delta T Cells in Diseases of the Central Nervous System

Jin Wo et al.

FRONTIERS IN IMMUNOLOGY (2020)

Editorial Material Clinical Neurology

Higher Incidence of Ischemic Stroke in Young Women Than in Young Men Mind the Gap

Merel S. Ekker et al.

STROKE (2020)

Review Biochemistry & Molecular Biology

CD4 T Helper Cell Subsets and Related Human Immunological Disorders

Xiaoliang Zhu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Immunology

Peripherally-sourced myeloid antigen presenting cells increase with advanced aging

Pedram Honarpisheh et al.

BRAIN BEHAVIOR AND IMMUNITY (2020)

Article Biotechnology & Applied Microbiology

Bioinformatics Analysis of Gene Expression Profiles of Sex Differences in Ischemic Stroke

Wenhao Zhu et al.

BIOMED RESEARCH INTERNATIONAL (2019)

Article Endocrinology & Metabolism

Fatty Acid-Binding Protein 4 and Risk of Type 2 Diabetes, Myocardial Infarction, and Stroke: A Prospective Cohort Study

Krasimira Aleksandrova et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2019)

Article Neurosciences

Diabetic Stroke Promotes a Sexually Dimorphic Expansion of T Cells

Ladonya Jackson et al.

NEUROMOLECULAR MEDICINE (2019)

Review Cell Biology

The impact of sex and age on T cell immunity and ischemic stroke outcomes

Hilda Ahnstedt et al.

CELLULAR IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

Early Sex Differences in the Immune-Inflammatory Responses to Neonatal Ischemic Stroke

Sonia Villapol et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Cardiac & Cardiovascular Systems

Interleukin-18 in patients with acute coronary syndromes

Axel Akerblom et al.

CLINICAL CARDIOLOGY (2019)

Review Neurosciences

Sexually dimorphic microglia and ischemic stroke

Nadine Kerr et al.

CNS NEUROSCIENCE & THERAPEUTICS (2019)

Review Immunology

Dendritic Cells as Sensors, Mediators, and Regulators of Ischemic Injury

Helong Dai et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Immunology

Sex differences in vaccine-induced humoral immunity

Stephanie Fischinger et al.

SEMINARS IN IMMUNOPATHOLOGY (2019)

Article Hematology

T Cells Prevent Hemorrhagic Transformation in Ischemic Stroke by P-Selectin Binding

Angelica Salas-Perdomo et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

Review Pharmacology & Pharmacy

Molecular Mechanisms of T Cells Activation by Dendritic Cells in Autoimmune Diseases

Yu Tai et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Immunology

Human γδ T-Cell Control of Mucosal immunity and inflammation

Neil E. McCarthy et al.

FRONTIERS IN IMMUNOLOGY (2018)

Review Endocrinology & Metabolism

Sex differences in stroke: Challenges and opportunities

Cheryl D. Bushnell et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2018)

Review Clinical Neurology

The meningeal and choroidal infiltration routes for leukocytes in stroke

Corinne Benakis et al.

THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2018)

Review Immunology

Neutrophil extracellular traps in immunity and disease

Venizelos Papayannopoulos

NATURE REVIEWS IMMUNOLOGY (2018)

Review Neurosciences

Sex Differences in the Immune Response to Experimental Stroke: Implications for Translational Research

Abby L. Dotson et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2017)

Review Peripheral Vascular Disease

Sex differences in stroke: Review of current knowledge and evidence

Raghavendra L. Girijala et al.

VASCULAR MEDICINE (2017)

Article Neurosciences

Neutrophil-to-Lymphocyte Ratio Is a Prognostic Marker in Acute Ischemic Stroke

Jie Xue et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2017)

Article Neurosciences

Neutrophil-to-Lymphocyte Ratio Is a Prognostic Marker in Acute Ischemic Stroke

Jie Xue et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2017)

Article Cell Biology

Sex differences in regulatory cells in experimental stroke

Hilary A. Seifert et al.

CELLULAR IMMUNOLOGY (2017)

Article Clinical Neurology

Neutrophil Extracellular Traps in Ischemic Stroke Thrombi

Elodie Laridan et al.

ANNALS OF NEUROLOGY (2017)

Article Cell Biology

Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones

Louise D. McCullough et al.

AGING-US (2016)

Article Cardiac & Cardiovascular Systems

Influence of Gender and Age on the Peripheral Immune Response in Stroke

Amy Miner Ross et al.

JOURNAL OF CARDIOVASCULAR NURSING (2016)

Article Endocrinology & Metabolism

Loss of PPARα perpetuates sex differences in stroke reflected by peripheral immune mechanisms

Abby L. Dotson et al.

METABOLIC BRAIN DISEASE (2016)

Article Biochemistry & Molecular Biology

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

Corinne Benakis et al.

NATURE MEDICINE (2016)

Review Clinical Neurology

Blood-brain barrier breakdown and neovascularization processes after stroke and traumatic brain injury

Roshini Prakash et al.

CURRENT OPINION IN NEUROLOGY (2015)

Review Endocrinology & Metabolism

Targeting neutrophils in ischemic stroke: translational insights from experimental studies

Glen C. Jickling et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2015)

Article Immunology

Sexually dimorphic outcomes and inflammatory responses in hypoxic-ischemic encephalopathy

Mehwish A. Mirza et al.

JOURNAL OF NEUROINFLAMMATION (2015)

Letter Endocrinology & Metabolism

Sex differences and the role of IL-10 in ischemic stroke recovery

Sarah E. Conway et al.

BIOLOGY OF SEX DIFFERENCES (2015)

Review Clinical Neurology

A Starring Role for Microglia in Brain Sex Differences

Kathryn M. Lenz et al.

NEUROSCIENTIST (2015)

Review Endocrinology & Metabolism

The immune system and aging: a review

Camil Castelo-Branco et al.

GYNECOLOGICAL ENDOCRINOLOGY (2014)

Article Neurosciences

Differential effects of aging and sex on stroke induced inflammation across the lifespan

Bharti Manwani et al.

EXPERIMENTAL NEUROLOGY (2013)

Article Clinical Neurology

Phenotypic Changes in Immune Cell Subsets Reflect Increased Infarct Volume in Male vs. Female Mice

Anirban Banerjee et al.

TRANSLATIONAL STROKE RESEARCH (2013)

Article Cell Biology

Gender effect on in vitro lymphocyte subset levels of healthy individuals

Maha Abdullah et al.

CELLULAR IMMUNOLOGY (2012)

Review Biochemistry & Molecular Biology

The Protective Effects of Natural Products on Blood-Brain Barrier Breakdown

A. Kam et al.

CURRENT MEDICINAL CHEMISTRY (2012)

Article Endocrinology & Metabolism

Effects of gender on gene expression in the blood of ischemic stroke patients

Yingfang Tian et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)

Article Immunology

Elevated serum levels of interleukin-17A in children with autism

Laila Yousef AL-Ayadhi et al.

JOURNAL OF NEUROINFLAMMATION (2012)

Review Immunology

Migration of γδ T cells in steady-state conditions

Sudhanshu Shekhar et al.

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY (2012)

Article Biochemistry & Molecular Biology

Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1

Angela Meier et al.

NATURE MEDICINE (2009)

Review Clinical Neurology

Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes

Mathew J. Reeves et al.

LANCET NEUROLOGY (2008)

Article Endocrinology & Metabolism

T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation

Patricia D. Hurn et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2007)

Article Surgery

Beneficial versus detrimental effects of neutrophils are determined by the nature of the insult

Mario Perl et al.

JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS (2007)

Article Clinical Neurology

Two subsets of dendritic cells are present in human cerebrospinal fluid

M Pashenkov et al.

BRAIN (2001)