Journal
STEM CELL RESEARCH
Volume 60, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.scr.2022.102707
Keywords
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Funding
- National Research Foundation (NRF) of Korea - Korea government (MSIT) [2021R1I1A1A01042945, 2021R1I1A1A01060135, 2019R1C1C1002334]
- Faculty research grant of Yonsei University College of Medicine [6-2021-0058]
- Korea Food Research Institute - Ministry of Science, ICT & Future Planning [E0210400]
- National Research Foundation of Korea [2019R1C1C1002334, 2021R1I1A1A01042945, 2021R1I1A1A01060135] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In this study, a human-induced pluripotent stem cell (hiPSC) line was generated from a patient with dilated cardiomyopathy (DCM). The hiPSC line showed normal karyotype and high expression of pluripotency markers, and its differentiation potential was confirmed by staining of three germ layer markers.
Dilated cardiomyopathy (DCM) is one of the leading causes of heart transplantation. The clinical feature of DCM is characterized by enlarged heart and impaired function of the left or both ventricles, while its etiology is varied. In this study, we generated YCMi005-A, a human-induced pluripotent stem cell (hiPSC) line from a patient with DCM carrying the missense mutation of p.Glu192Lys in the TPM1 genes. YCMi005-A, an established hiPSC, showed the normal karyotype (46, XX) and high expression of pluripotency markers. In addition, it was confirmed that YCMi005-A has the differentiation potential assessed by staining of three germ layer markers.
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