Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 271, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2022.120880
Keywords
Omarigliptin; Spectrophotometry; Univariate; Multivariate; Stability indicating
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Several selective spectrophotometric techniques were developed for the determination of the antidiabetic drug omarigliptin and its degradation products. The methods were validated and found to be effective for quantification and quality control purposes.
Six selective spectrophotometric techniques, four univariate and two multivariate ones were developed for the determination of the antidiabetic drug omarigliptin (OMR) along with its hydrolytic and oxidative degradation products. The proposed univariate spectrophotometric methods were ratio subtraction, first derivative, derivative ratio and ratio difference. Linearities were constructed in the range of 10.0-180.0 mu g mL(-1) for both OMR & its hydrolytic degradation product and 10.0-110.0 mu g mL(-1) for the oxidative degradation one. On the other hand, partial least squares and artificial neural networks were the chosen multivariate approaches. Their linearity ranges were 20.0-60.0 mu g mL(-1) for OMR and 10.0-30.0 mu g mL(-1) for the two degradation products. All the methods were validated, effectively applied for quantification of the intact drug in its tablet formulation and favorably compared to the reported one. (C) 2022 Elsevier B.V. All rights reserved.
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