Au3+-Functionalized UiO-67 Metal-Organic Framework Nanoparticles: O2•- and •OH Generating Nanozymes and Their Antibacterial Functions

The synthesis and characterization of Au3+-modified UiO-67 metal-organic framework nanoparticles, Au3+-NMOFs, are described. The Au3+-NMOFs reveal dual oxidase-like and peroxidase-like activities and act as an active catalyst for the catalyzed generation of O-2(center dot-) under aerobic conditions or center dot OH in the presence of H2O2. The two reactive oxygen species (ROS) agents O-2(center dot-) and center dot OH are cooperatively formed by Au3+-NMOFs under aerobic conditions, and in the presence of H2O2. The Au3+-NMOFs are applied as an effective catalyst for the generation ROS agents for antibacterial and wound healing applications. Effective antibacterial cell death and inhibition of cell proliferation of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacterial colonies are demonstrated in the presence of the Au3+-NMOFs. In addition, in vivo experiments demonstrate effective wound healing of mice wounds infected by S. aureus, treated by the Au3+-NMOFs.

Automated summary

In this study, the synthesis and characterization of Au3+-modified UiO-67 metal-organic framework nanoparticles were described. The Au3+-NMOFs showed dual oxidase-like and peroxidase-like activities, and acted as an effective catalyst for the generation of ROS agents for antibacterial and wound healing applications.