Journal
JOURNAL OF APPLIED POLYMER SCIENCE
Volume 133, Issue 28, Pages -Publisher
WILEY
DOI: 10.1002/app.43648
Keywords
clay; degradation; polyesters
Categories
Funding
- Basque Goverment
- UPV/EHU [UFI11/56]
- UPV/EHU Infrastructure: INF [14/38]
- Mineco/FEDER: SINF [130I001726XV1/ UNPV13-4E-1726]
- Mineco [MAT2014-53437-C2-P]
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Hydrolytic degradation of a nanocomposite of poly(L-lactic acid), PLA, and a layered double hydroxide (LDH) modified with the drug 4-biphenyl acetic acid (Bph) has been studied. PLA/LDH-Bph nanocomposite was prepared by solvent casting with 5 wt % of drug modified LDH and the hydrolytic degradation was carried out in a PBS solution at pH 7.2 and 37 degrees C. Neat PLA with 5 wt % 4-biphenyl acetic acid was studied as reference material (PLA/Bph). The materials were studied by WAXS, TEM, TGA, DSC, SEM, FTIR, SEC and contact angle measurements. For PLA/Bph, an acid catalytic effect, caused by the drug, accelerates PLA mass loss. However, for PLA/LDH-Bph, the presence of LDH produces a barrier effect that initially reduces the diffusion of the oligomers produced during hydrolytic degradation. DSC results demonstrate that Bph induces faster PLA crystallization and this effect is reduced in PLA/LDH-Bph nanocomposites because of their lower drug content. (c) 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43648.
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