4.6 Review

A unifying model for extrachromosomal circular DNA load in eukaryotic cells

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Circular DNA in the human germline and its association with recombination

Rasmus Amund Henriksen et al.

Summary: Extrachromosomal circular DNA (eccDNA) is present in the human germline, derived from all genomic regions, and can have transient and permanent effects on germline cells.

MOLECULAR CELL (2022)

Article Cell Biology

Mispair-bound human MutS-MutL complex triggers DNA incisions and activates mismatch repair

Janice Ortega et al.

Summary: The study reveals that the sliding of MutS alpha is necessary for mismatch removal in MMR, MutS alpha recruits MutL alpha to form a mismatch-bound complex and initiates MMR by nicking the daughter strand 5' to the mismatch, Exo1 conducts excision, solving the mechanism of MMR initiation and mispair removal.

CELL RESEARCH (2021)

Article Multidisciplinary Sciences

ecDNA hubs drive cooperative intermolecular oncogene expression

King L. Hung et al.

Summary: Extrachromosomal DNA (ecDNA) hubs are clusters of ecDNAs within the nucleus that enable intermolecular enhancer-gene interactions, promoting oncogene overexpression. The protein-tethered ecDNA hubs facilitate intermolecular transcriptional regulation, serving as units of oncogene function and potential targets for cancer therapy.

NATURE (2021)

Article Multidisciplinary Sciences

eccDNAs are apoptotic products with high innate immunostimulatory activity

Yuangao Wang et al.

Summary: By developing a new eccDNA purification and profiling method, the study revealed close-to-random genomic origination, mechanism of biogenesis and function of eccDNAs.

NATURE (2021)

Article Biochemistry & Molecular Biology

MicroDNA levels are dependent on MMEJ, repressed by c-NHEJ pathway, and stimulated by DNA damage

Teressa Paulsen et al.

Summary: This study suggests that microDNA levels are influenced by resection after double-strand DNA break (DSB) and repair by Microhomology Mediated End Joining (MMEJ). The accumulation of microDNA occurs during DNA repair pathways following endogenous or induced DNA breaks.

NUCLEIC ACIDS RESEARCH (2021)

Article Oncology

Oncogenic extrachromosomal DNA functions as mobile enhancers to globally amplify chromosomal transcription

Yanfen Zhu et al.

Summary: The study reveals that extrachromosomal, circular DNA (ecDNA) is a common and oncogenic alteration in cancer genomes, impacting transcriptional programs through chromatin interactions. ecDNAs in neurosphere and prostate cancer cell cultures show widespread intra-ecDNA and genome-wide chromosomal interactions, potentially leading to high-level expression of chromosomal genes.

CANCER CELL (2021)

Review Genetics & Heredity

The dynamic nuclear periphery as a facilitator of gamete health and rejuvenation

Grant A. King et al.

CURRENT GENETICS (2020)

Article Genetics & Heredity

Extrachromosomal circular DNA drives oncogenic genome remodeling in neuroblastoma

Richard P. Koche et al.

NATURE GENETICS (2020)

Review Genetics & Heredity

The adaptive potential of circular DNA accumulation in ageing cells

Ryan M. Hull et al.

CURRENT GENETICS (2020)

Review Biochemistry & Molecular Biology

Extrachromosomal Circular DNA: Current Knowledge and Implications for CNS Aging and Neurodegeneration

Quratul Ain et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Mechanisms generating cancer genome complexity from a single cell division error

Neil T. Umbreit et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma

Konstantin Helmsauer et al.

NATURE COMMUNICATIONS (2020)

Article Clinical Neurology

Structure and evolution of double minutes in diagnosis and relapse brain tumors

Ke Xu et al.

ACTA NEUROPATHOLOGICA (2019)

Review Cell Biology

The DNA damage response to transcription stress

Hannes Lans et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Programmed genome rearrangements in Oxytricha produce transcriptionally active extrachromosomal circular DNA

V. Talya Yerlici et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemistry & Molecular Biology

Functional Enhancers Shape Extrachromosomal Oncogene Amplifications

Andrew R. Morton et al.

Article Multidisciplinary Sciences

Circular ecDNA promotes accessible chromatin and high oncogene expression

Sihan Wu et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Transcription-induced formation of extrachromosomal DNA during yeast ageing

Ryan M. Hull et al.

PLOS BIOLOGY (2019)

Review Oncology

Extrachromosomal oncogene amplification in tumour pathogenesis and evolution

Roel G. W. Verhaak et al.

NATURE REVIEWS CANCER (2019)

Article Multidisciplinary Sciences

Extrachromosomal circular DNA-based amplification and transmission of herbicide resistance in crop weed Amaranthus palmeri

Dal-Hoe Koo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Circular DNA elements of chromosomal origin are common in healthy human somatic tissue

Henrik Devitt Moller et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors

Manasi Ratnaparkhe et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity

Kristen M. Turner et al.

NATURE (2017)

Editorial Material Genetics & Heredity

Copy number alterations unmasked as enhancer hijackers

Rameen Beroukhim et al.

NATURE GENETICS (2017)

Review Cell Biology

Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis

Peter Ly et al.

TRENDS IN CELL BIOLOGY (2017)

Review Genetics & Heredity

The Dual Roles of MYC in Genomic Instability and Cancer Chemoresistance

Alpana Kumari et al.

GENES (2017)

Review Biotechnology & Applied Microbiology

Ribosomal DNA stability is supported by many 'buffer genes'-introduction to the Yeast rDNA Stability Database

Takehiko Kobayashi et al.

FEMS YEAST RESEARCH (2017)

Review Toxicology

Impaired nuclear functions in micronuclei results in genome instability and chromothripsis

Mariona Terradas et al.

ARCHIVES OF TOXICOLOGY (2016)

Article Multidisciplinary Sciences

Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells

Henrik D. Moller et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2016)

Article Multidisciplinary Sciences

Chromothripsis from DNA damage in micronuclei

Cheng-Zhong Zhang et al.

NATURE (2015)

Article Multidisciplinary Sciences

Extrachromosomal circular DNA is common in yeast

Henrik D. Moller et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

Paul A. Northcott et al.

NATURE (2014)

Article Multidisciplinary Sciences

Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA

David A. Nathanson et al.

SCIENCE (2014)

Article Multidisciplinary Sciences

Extrachromosomal MicroDNAs and Chromosomal Microdeletions in Normal Tissues

Yoshiyuki Shibata et al.

SCIENCE (2012)

Article Biochemistry & Molecular Biology

Bet Hedging in Yeast by Heterogeneous, Age-Correlated Expression of a Stress Protectant

Sasha F. Levy et al.

PLOS BIOLOGY (2012)

Article Biochemistry & Molecular Biology

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

Philip J. Stephens et al.

Article Biochemistry & Molecular Biology

Nuclear Geometry and Rapid Mitosis Ensure Asymmetric Episome Segregation in Yeast

Lutz R. Gehlen et al.

CURRENT BIOLOGY (2011)

Article Multidisciplinary Sciences

Circular DNA Intermediate in the Duplication of Nile Tilapia vasa Genes

Koji Fujimura et al.

PLOS ONE (2011)

Article Biochemistry & Molecular Biology

Gene amplification as double minutes or homogeneously staining regions in solid tumors: Origin and structure

Clelia Tiziana Storlazzi et al.

GENOME RESEARCH (2010)

Article Biochemistry & Molecular Biology

Extrachromosomal amplification mechanisms in a glioma with amplified sequences from multiple chromosome loci

Anne Gibaud et al.

HUMAN MOLECULAR GENETICS (2010)

Article Multidisciplinary Sciences

Emergence of Micronuclei and Their Effects on the Fate of Cells under Replication Stress

Koh-ichi Utani et al.

PLOS ONE (2010)

Article Multidisciplinary Sciences

Adaptation to diverse nitrogen-limited environments by deletion or extrachromosomal element formation of the GAP1 locus

David Gresham et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Editorial Material Cell Biology

Laminin deposition in the extracellular matrix: a complex picture emerges

Kevin J. Hamill et al.

JOURNAL OF CELL SCIENCE (2009)

Article Biochemistry & Molecular Biology

Analysis of repair mechanism choice during homologous recombination

Neta Agmon et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Multidisciplinary Sciences

Eukaryote-to-eukaryote gene transfer events revealed by the genome sequence of the wine yeast Saccharomyces cerevisiae EC1118

Maite Novo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution

Graham R. Bignell et al.

GENOME RESEARCH (2007)

Review Genetics & Heredity

Finely orchestrated movements: Evolution of the ribosomal RNA genes

Thomas H. Eickbush et al.

GENETICS (2007)

Article Biochemistry & Molecular Biology

Mouse major satellite DNA is prone to eccDNA formation via DNA Ligase IV-dependent pathway

Z. Cohen et al.

ONCOGENE (2006)

Article Multidisciplinary Sciences

Recombination regulation by transcription-induced cohesin dissociation in rDNA repeats

T Kobayashi et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

Amplification of telomeric arrays via rolling-circle mechanism

J Nosek et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas

N Vogt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Telomeric DNA in ALT cells is characterized by free telomeric circles and heterogeneous t-loops

AJ Cesare et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Extrachromosomal circular DNA of tandemly repeated genomic sequences in Drosophila

S Cohen et al.

GENOME RESEARCH (2003)

Article Biotechnology & Applied Microbiology

The correlation between rDNA copy number and genome size in eukaryotes

CD Prokopowich et al.

GENOME (2003)

Article Biochemistry & Molecular Biology

The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication fork

T Kobayashi

MOLECULAR AND CELLULAR BIOLOGY (2003)

Article Biochemistry & Molecular Biology

c-Myc initiates illegitimate replication of the ribonucleotide reductase R2 gene

TI Kuschak et al.

ONCOGENE (2002)

Article Biotechnology & Applied Microbiology

Selective elimination of acentric double minutes from cancer cells through the extrusion of micronuclei

N Shimizu et al.

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2000)