Seizure and social outcomes in patients with juvenile myoclonic epilepsy (JME)

Objectives: To investigate the seizure outcome in patients with juvenile myoclonic epilepsy (JME) and its associated factors. We also investigated the social outcome of these patients. Methods: This was a retrospective study. All patients with a diagnosis of JME were studied at the outpatient epilepsy clinic at Shiraz University of Medical Sciences, Shiraz, Iran, from 2008 until 2019. In a phone call to the patients, at least 24 months after their diagnosis at our center, we investigated their current seizure control state and social status. Results: One hundred and thirty-five patients were studied [92 women (68.1%) and 43 men (31.9%)]. Fifty-three patients (39.3%) were seizure-free (of all seizure types) during the past 12 months; 91 patients (67.4%) reported to be free of generalized tonic-clonic seizures. At the time of the follow-up call, 71 patients (52.6%) reported having a college education, 56 patients (41.5%) were employed, 87 patients (64.4%) were married, and 57 patients (42.2%) reported driving a motor vehicle in their routine daily lives. In total, 101 patients (74.8%) reported that their status (generally, and considering all the variables) was better than that it used to be five years ago. Conclusion: We may conclude that JME at tertiary referral centers is not as benign as it was suggested by some authors before. Furthermore, the employment status of patients with JME is significantly worse than that in the corresponding general populations. However, most patients with JME may enjoy marital status and educational levels comparable to those by the general public.

Automated summary

This study investigated the seizure and social outcomes of patients with juvenile myoclonic epilepsy (JME) and found that JME at tertiary referral centers is not as benign as previously suggested. The employment status of JME patients is significantly worse compared to the general population. However, most JME patients have marital status and educational levels comparable to the general public.