4.8 Article

Innate PD-L1 limits T cell-mediated adipose tissue inflammation and ameliorates diet-induced obesity

Related references

Note: Only part of the references are listed.
Article Immunology

PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance

Catherine L. Tan et al.

Summary: Studies have shown that PD-1-deficient T reg cells exhibit enhanced immunosuppressive function through reduced signaling through the PI3K-AKT pathway. This finding demonstrates that cell-intrinsic PD-1 restraint of T reg cells is a significant mechanism by which PD-1 inhibitory signals regulate T cell tolerance and autoimmunity.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Immunology

Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

Andrew D. Hildreth et al.

Summary: This study provides a comprehensive analysis of the cellular composition in healthy and obese human white adipose tissue, revealing changes in immune cell populations and inflammatory pathways in obese individuals. The findings highlight the importance of immune cell regulation in metabolic diseases and offer insights into new cellular networks and differentiation trajectories in white adipose tissue.

NATURE IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Sex-specific adipose tissue imprinting of regulatory T cells

Ajithkumar Vasanthakumar et al.

NATURE (2020)

Article Multidisciplinary Sciences

PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

Doumet Georges Helou et al.

NATURE COMMUNICATIONS (2020)

Article Immunology

A stromal cell niche sustains ILC2-mediated type-2 conditioning in adipose tissue

Batika M. J. Rana et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Biochemistry & Molecular Biology

Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade

Ziming Wang et al.

NATURE MEDICINE (2019)

Article Endocrinology & Metabolism

Collateral Damage: Insulin-Dependent Diabetes Induced With Checkpoint Inhibitors

Angeliki Stamatouli et al.

DIABETES (2018)

Article Medicine, Research & Experimental

PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation

Alessandra Petrelli et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Immunology

ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control

Christian Schwartz et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Article Multidisciplinary Sciences

PD-L1 is an activation-independent marker of brown adipocytes

Jessica R. Ingram et al.

NATURE COMMUNICATIONS (2017)

Review Immunology

Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System

Cornelia Symowski et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Medicine, Research & Experimental

Obesity accelerates T cell senescence in murine visceral adipose tissue

Kohsuke Shirakawa et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Immunology

IL-12 drives functional plasticity of human group 2 innate lymphoid cells

Ai Ing Lim et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

Article Biochemical Research Methods

Inducible targeting of cDCs and their subsets in vivo

Jakob Loschko et al.

JOURNAL OF IMMUNOLOGICAL METHODS (2016)

Article Immunology

Differential control of CD4+ T-cell subsets by the PD-1/PD-L1 axis in a mouse model of allergic asthma

Jaclyn W. McAlees et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

Article Biochemistry & Molecular Biology

Lipid-Overloaded Enlarged Adipocytes Provoke Insulin Resistance Independent of Inflammation

Jong In Kim et al.

MOLECULAR AND CELLULAR BIOLOGY (2015)

Article Gastroenterology & Hepatology

Protective effects of Fc-fused PD-L1 on two different animal models of colitis

Mi-Young Song et al.

Article Multidisciplinary Sciences

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

Jonathan R. Brestoff et al.

NATURE (2015)

Article Hematology

T-Cell Profile in Adipose Tissue Is Associated With Insulin Resistance and Systemic Inflammation in Humans

Tracey McLaughlin et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2014)

Article Multidisciplinary Sciences

Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance

Saul J. Priceman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Immunology

Immunological complications of obesity

Thirumala-Devi Kanneganti et al.

NATURE IMMUNOLOGY (2012)

Article Pediatrics

An early inflammatory gene profile in visceral adipose tissue in children

Charmaine S. Tam et al.

INTERNATIONAL JOURNAL OF PEDIATRIC OBESITY (2011)

Article Biochemistry & Molecular Biology

Interferon γ Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway

Fiona C. McGillicuddy et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Immunology

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

Loise M. Francisco et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2009)

Article Biochemistry & Molecular Biology

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Satoshi Nishimura et al.

NATURE MEDICINE (2009)

Article Biochemistry & Molecular Biology

Normalization of obesity-associated insulin resistance through immunotherapy

Shawn Winer et al.

NATURE MEDICINE (2009)

Review Immunology

PD-1 and its ligands in tolerance and immunity

Mary E. Keir et al.

ANNUAL REVIEW OF IMMUNOLOGY (2008)

Article Endocrinology & Metabolism

Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration

M. E. Rausch et al.

INTERNATIONAL JOURNAL OF OBESITY (2008)

Article Immunology

Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen

Michele L. Caton et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

Article Psychology, Mathematical

G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences

Franz Faul et al.

BEHAVIOR RESEARCH METHODS (2007)