Fabrication of subunit nanovaccines by physical interaction

Vaccines can improve the quality of human life by preventing the burden of infectious diseases. Also, vaccination is becoming a powerful medication for preventing and treating tumors. Various vaccines have been developed based on the origin of the antigens. Herein, we focus on the subunit vaccines whose antigens are proteins or peptides. The advantage of subunit vaccines is safety for recipients; however, the immunogenicity of subunit antigens is relatively low. Nanoparticular delivery systems have been applied to improve the immunocompetence of subunit vaccines by targeting lymph nodes, and effectively present antigens to immune cells. Moreover, adding appropriate molecular adjuvants may strengthen the antigens to elicit immune response. In this perspective article, we first elucidate the characteristics of immunity induced by subunit nanovaccines and then summarize the strategies to fabricate subunit nanovaccines with delivering materials. Herein we highlight non-covalent interaction to fabricate nanoparticular subunit vaccines.

Automated summary

Vaccines can improve human life by preventing infectious diseases and can also be used for tumor prevention and treatment. Subunit vaccines, which have antigens in the form of proteins or peptides, offer safety to recipients but have relatively low immunogenicity. Nanoparticular delivery systems and molecular adjuvants can enhance the immunocompetence of subunit vaccines.