Comment on Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

Article Multidisciplinary Sciences

Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

J. Terreros-Roncal et al.

Summary: Disrupted hippocampal performance is a major factor contributing to psychiatric comorbidities and cognitive impairments in patients with neurodegenerative disorders. Adult hippocampal neurogenesis (AHN) plays a crucial role in several neurodegenerative diseases, with abnormalities found in adult-born dentate granule cells. Aging and diseases alter the neurogenic niche, reduce microglial phagocytic capacity, trigger astrogliosis, and change the microvasculature of the dentate gyrus, leading to enhanced vulnerability of AHN to neurodegeneration.

SCIENCE (2021)

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Article Neurosciences

Positive Controls in Adults and Children Support That Very Few, If Any, New Neurons Are Born in the Adult Human Hippocampus

Shawn F. Sorrells et al.

Summary: Adult hippocampal neurogenesis was initially discovered in rodents, with subsequent studies identifying adult neural stem cells and their links to plasticity, behavior, and disease. The debate continues as to whether new neurons are produced in the human dentate gyrus during healthy aging. Recent research has shown conflicting results regarding the presence of dividing neuronal precursors in the adult human brain.

JOURNAL OF NEUROSCIENCE (2021)

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Article Neurosciences

Evidences for Adult Hippocampal Neurogenesis in Humans

Elena P. Moreno-Jimenez et al.

Summary: The rodent hippocampus generates new neurons throughout life, but direct evidence of adult neurogenesis in humans remains elusive. Research indicates that adult hippocampal neurogenesis may persist until the 10th decade of human life, with marked impairments in patients with Alzheimer's disease. Methodological aspects in processing and analyzing postmortem human brain samples may limit the detection of markers of adult hippocampal neurogenesis, highlighting the need for strict controls in human studies.

JOURNAL OF NEUROSCIENCE (2021)

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Article Cell Biology