Journal
SCIENCE
Volume 376, Issue 6590, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abn8861
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Funding
- NIH [P01 NS083513, K08 NS091537, R01 NS028478]
- Roberta and Oscar Gregory Endowment in Stroke and Brain Research
- Valencian Council for Innovation, Universities, Sciences and Digital Society [PROMETEO/2019/075]
- Red de Terapia Celular [TerCel-RD16/0011/0026]
- Spanish Generalitat Valenciana
- European Social Fund postdoctoral fellowship [APOSTD2018/A113]
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This study lacks evidence to support the link between proliferating cells and neurogenesis, the role of multipolar nestin(+) astrocytes as progenitors, and the identity of mature-looking doublecortin+ neurons as adult-born. The histology-marker expression observed differs from species with well-documented adult hippocampal neurogenesis.
Terreros-Roncal et al. investigated the impacts of human neurodegeneration on immunostainings assumed to be associated with neurogenesis. However, the study provides no evidence that putative proliferating cells are linked to neurogenesis, that multipolar nestin(+) astrocytes are progenitors, or that mature-looking doublecortin+ neurons are adult-born. Their histology-marker expression differs from what is observed in species where adult hippocampal neurogenesis is well documented.
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