Journal
SCIENCE
Volume 376, Issue 6599, Pages 1284-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abh3104
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Funding
- Israel Science Foundation-Singapore National Research Foundation joint research program [3291/19]
- Ben Schender Fund for Outstanding Young Scientists
- Dr. Gabrielle Reem-Kayden Scholarship
- HUJI International PhD Talent Scholarship
- Abisch-Frenkel Scholarship for Scientific Excellence
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A cilium has been identified in oocytes, which counterbalances telomere pulling and is essential for bouquet and synaptonemal complex formation, oogenesis, ovarian development, and fertility.
A hallmark of meiosis is chromosomal pairing, which requires telomere tethering and rotation on the nuclear envelope through microtubules, driving chromosome homology searches. Telomere pulling toward the centrosome forms the zygotene chromosomal bouquet. Here, we identified the zygotene cilium in oocytes. This cilium provides a cable system for the bouquet machinery and extends throughout the germline cyst. Using zebrafish mutants and live manipulations, we demonstrate that the cilium anchors the centrosome to counterbalance telomere pulling. The cilium is essential for bouquet and synaptonemal complex formation, oogenesis, ovarian development, and fertility. Thus, a cilium represents a conserved player in zebrafish and mouse meiosis, which sheds light on reproductive aspects in ciliopathies and suggests that cilia can control chromosomal dynamics.
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