Journal
SCIENCE
Volume 376, Issue 6595, Pages 817-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abn6204
Keywords
-
Categories
Funding
- Fonds de la Recherche Scientifique (FRS) Fonds National de la Recherche Scientifique (FNRS)
- Excellence of Science [0019118F-RG36]
- Fonds Leon Fredericq
- Fondation Medicale Reine Elisabeth
- Fondation Simone et Pierre Clerdent
- Belgian Science Policy (IAP-VII network) [P7/20]
- ERANET Neuron (STEM-MCD) [2010126]
Ask authors/readers for more resources
During embryogenesis, vOPCs and cortical interneurons interact and occupy mutually exclusive territories in the forebrain. First-wave vOPCs play a crucial role in steering the migration of cortical interneurons away from blood vessels, allowing them to reach their proper cortical territories.
In the forebrain, ventrally derived oligodendrocyte precursor cells (vOPCs) travel tangentially toward the cortex together with cortical interneurons. Here, we tested in the mouse whether these populations interact during embryogenesis while migrating. By coupling histological analysis of genetic models with live imaging, we show that although they are both attracted by the chemokine Cxcl12, vOPCs and cortical interneurons occupy mutually exclusive forebrain territories enriched in this chemokine. Moreover, first-wave vOPC depletion selectively disrupts the migration and distribution of cortical interneurons. At the cellular level, we found that by promoting unidirectional contact repulsion, first-wave vOPCs steered the migration of cortical interneurons away from the blood vessels to which they were both attracted, thereby allowing interneurons to reach their proper cortical territories.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available