Longitudinal symptom changes and association with home time in people with schizophrenia: An observational digital phenotyping study

Article Medicine, General & Internal

A novel way to quantify schizophrenia symptoms in clinical trials

Oleg N. Medvedev et al.

Summary: By applying Generalizability Theory, we were able to distinguish between dynamic and enduring aspects of schizophrenia symptoms, with attention, delusions, blunted affect, and poor rapport being identified as the most enduring symptoms, while grandiosity, preoccupation, somatic concerns, guilt feeling, and hallucinatory behavior appeared more dynamic and amendable to change. Targeting these dynamic symptoms in interventions could lead to more effective treatment of schizophrenia and increase sensitivity in clinical trials.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Clinical Neurology

Digital phenotyping and the COVID-19 pandemic: Capturing behavioral change in patients with psychiatric disorders

Raj R. Jagesar et al.

Summary: The COVID-19 pandemic has led to unprecedented societal changes, limiting mobility and in-person interactions. This has provided a unique opportunity for studies using digital phenotyping tools, which have shown potential in improving behavioral research. Research findings indicated that during the pandemic, there was an increase in communication time and a decrease in mobility, while time spent at home remained relatively stable.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2021)

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Article Psychiatry

Schizophrenia and the Environment: Within-Person Analyses May be Required to Yield Evidence of Unconfounded and Causal Association-The Example of Cannabis and Psychosis

Jim van Os et al.

Summary: This study used a within-person design to show a prospective association between prior cannabis use and psychotic experiences. The results suggest that cannabis likely impacts causally on psychosis rather than the other way round.

SCHIZOPHRENIA BULLETIN (2021)

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Article Psychiatry

Self-reported social functioning and social cognition in schizophrenia and bipolar disorder: Using ecological momentary assessment to identify the origin of bias

Dante Durand et al.

Summary: The study found a cognitive bias in self-reported functioning among individuals with schizophrenia and bipolar illness, with a disconnect between momentary experiences and self-reports. Observer ratings were highly correlated with momentary survey results, and patients who were commonly home and alone reported better social functioning compared to those who spent more time with others.

SCHIZOPHRENIA RESEARCH (2021)

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Article Psychiatry

Digital phenotyping adherence, feasibility, and tolerability in outpatients with schizophrenia

Ian M. Raugh et al.

Summary: Digital phenotyping shows promise as an objective and ecologically valid form of symptom assessment in clinical trials for schizophrenia. The study evaluated adherence, feasibility, and tolerability levels for active and passive digital phenotyping methods, finding that passive recordings had higher adherence than active recordings, with ambulatory psychophysiology showing the lowest adherence among passive methods.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

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Article Neuroimaging