Journal
RUSSIAN JOURNAL OF DEVELOPMENTAL BIOLOGY
Volume 53, Issue 2, Pages 141-144Publisher
PLEIADES PUBLISHING INC
DOI: 10.1134/S1062360422020023
Keywords
aryl hydrocarbon receptor AHR; histone deacetylase HDAC; belinostat; CYP1B
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Funding
- Government program of basic research in Koltzov Institute of Developmental Biology, Russian Academy of Sciences [0088-2021-0007]
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The study shows for the first time an increase in the expression of aryl hydrocarbon receptor gene and its target genes in human cell cultures after exposure to a histone deacetylase inhibitor (belinostat). Belinostat is currently being considered as a possible therapeutic agent for treating various types of gliomas, including glioblastomas.
Aryl hydrocarbon receptor (AHR) is a highly conserved ligand-dependent transcription factor, whose target genes play a key role in detoxification, regulation of developmental processes, maintenance of eukaryotic homeostasis, and metabolism of medicinal compounds. This study demonstrates for the first time an increase in the expression of the aryl hydrocarboxylic receptor gene and its target genes in human cell cultures after exposure to a histone deacetylase inhibitor (belinostat), which is currently being considered as a possible therapeutic agent for the treatment of various types of gliomas, including glioblastomas.
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