Journal
JOURNAL OF APPLIED PHYSIOLOGY
Volume 120, Issue 1, Pages 17-28Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00543.2015
Keywords
flow patterns; diffusing capacity; porous medium; histomorphometry; experimental techniques
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Funding
- International Relations Department of Ecole Polytechnique
- Placental Analytics, SAMOVAR Project of the Agence Nationale de Recherche [2010-BLAN-1119-05]
- Agence Nationale de Recherche Project [ANR-13JSV5-0006-01]
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The performance of the placenta as a gas exchanger has a direct impact on the future health of the newborn. To provide accurate estimates of respiratory gas exchange rates, placenta models need to account for both the physiology of exchange and the organ morphology. While the former has been extensively studied, accounting for the latter is still a challenge. The geometrical complexity of placental structure requires use of carefully crafted approximations. We present here the state of the art of respiratory gas exchange placenta modeling and demonstrate the influence of the morphology description on model predictions. Advantages and shortcomings of various classes of models are discussed, and experimental techniques that may be used for model validation are summarized. Several directions for future development are suggested.
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