Journal
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
Volume 25, Issue 1, Pages 127-134Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1055-9965.EPI-15-0822
Keywords
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Funding
- Wereld Kanker Onderzoek Fonds (WCRF NL) [WCRF 2011/442]
- Health Research Fund (FIS) of the Spanish Ministry of Health [Exp PI11/01473]
- European Commission (DG-SANCO)
- International Agency for Research on Cancer
- Health Research Fund (FIS) of the Spanish Ministry of Health
- Regional Government of Andalucia
- Regional Government of Asturias
- Regional Government of Basque Country
- Regional Government of Murcia [6236]
- Regional Government of Navarra
- Catalan Institute of Oncology
- La Caixa [BM 06-130]
- Red Tematica de Investigacion Cooperativa en Cancer (Spain) [RD12/0036/0018, RD06/0020/0091]
- Danish Cancer Society (Denmark)
- Ligue contre le Cancer
- Institut Gustave Roussy
- Mutuelle Generale de l'Education Nationale
- Institut National de la Sante et de la Recherche Medicale (INSERM) (France)
- Deutsche Krebshilfe
- Deutsches Krebsforschungszentrum (DKFZ)
- Federal Ministry of Education and Research (Germany)
- Hellenic Health Foundation (Greece)
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- National Research Council (Italy)
- Dutch Ministry of Public Health, Welfare, and Sports
- Netherlands Cancer Registry
- LK Research Funds
- Dutch Prevention Funds
- Dutch ZON (Zorg Onderzoek Nederland)
- World Cancer Research Fund (WCRF)
- Statistics Netherlands (The Netherlands)
- Nordic Center of Excellence in Food, Nutrition, and Health-Helga (Norway)
- Swedish Cancer Society
- Swedish Scientific Council
- Regional Government of Vasterbotten (Sweden)
- Cancer Research UK [C570/A16491, 14136]
- Medical Research Council [G1000143, MC_UU_12015/1]
- Regional Government of Skane (Sweden)
- Cancer Research UK [16491] Funding Source: researchfish
- Medical Research Council [MC_U106179471, G0401527] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10114, NF-SI-0512-10135] Funding Source: researchfish
- MRC [MC_UU_12015/1] Funding Source: UKRI
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Background: Acrylamide was classified as probably carcinogenic to humans (group 2A) by the International Agency for Research on Cancer. Epithelial ovarian cancer (EOC) is the fourth cause of cancer mortality in women. Five epidemiological studies have evaluated the association between EOC risk and dietary acrylamide intake assessed using food frequency questionnaires, and one nested case-control study evaluated hemoglobin adducts of acrylamide (HbAA) and its metabolite glycidamide (HbGA) and EOC risk; the results of these studies were inconsistent. Methods: A nested case-control study in nonsmoking postmenopausal women (334 cases, 417 controls) was conducted within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Unconditional logistic regression models were used to estimate ORs and 95% confidence intervals (CI) for the association between HbAA, HbGA, HbAA+HbGA, and HbGA/HbAA and EOC and invasive serous EOC risk. Results: No overall associations were observed between biomarkers of acrylamide exposure analyzed in quintiles and EOC risk; however, positive associations were observed between some middle quintiles of HbGA and HbAA+HbGA. Elevated but non-statistically significant ORs for serous EOC were observed for HbGA and HbAA+HbGA (ORQ5vsQ1, 1.91; 95% CI, 0.96-3.81 and ORQ5vsQ1, 1.90; 95% CI, 0.94-3.83, respectively); however, no linear dose-response trends were observed. Conclusion: This EPIC nested case-control study failed to observe a clear association between biomarkers of acrylamide exposure and the risk of EOC or invasive serous EOC. Impact: It is unlikely that dietary acrylamide exposure increases ovarian cancer risk; however, additional studies with larger sample size should be performed to exclude any possible association with EOC risk. (C) 2015 AACR.
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