Synthesis, antimicrobial evaluation and docking studies of fluorinated imine linked 1,2,3-triazoles

A diverse series of imine linked 1,2,3-triazole hybrids has been synthesized via Cu(I)-promoted click reaction, with an aim to develop some new antimicrobial molecules. The structural characterization of the synthesized triazole hybrids was accomplished using various spectral techniques like H-1 NMR, C-13 NMR, FTIR and HRMS. Among the synthesized hybrids, 7d exhibited highest antimicrobial efficacy against R. oryzae and S. aureus with MIC of 0.0123 mu mol/mL and 0.0061 mu mol/mL, respectively. Docking studies of the terminal alkynes (4a, 4b) and triazole hybrids (6a, 6d, 7c, 7g) showing high potency towards E. coli DNA gyrase and C. albicans sterol 14-alpha demethylase were also undertaken to understand the binding behaviour. [GRAPHICS] .

Automated summary

A diverse series of imine linked 1,2,3-triazole hybrids were synthesized via Cu(I)-promoted click reaction, and their structures were characterized using various spectral techniques. Among them, 7d exhibited the highest antimicrobial activity against R. oryzae and S. aureus. Docking studies revealed that some triazole hybrids showed high potency towards E. coli DNA gyrase and C. albicans sterol 14-alpha demethylase.