Journal
RARE METALS
Volume 41, Issue 8, Pages 2701-2710Publisher
NONFERROUS METALS SOC CHINA
DOI: 10.1007/s12598-022-01978-3
Keywords
Rare earth; ZIF-8; Mesoporous silica; Long-term chemotherapy; Luminescence traceability; Nanocarrier
Funding
- Science Foundation of China University of Petroleum, Beijing [2462019BJRC001]
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In this study, a novel nanoplatform was developed for long-term and luminescence trackable chemotherapy. It involved a hollow ZIF-8 coated with Eu3+-doped mesoporous silica. The hollow ZIF-8 acted as a drug library, with pH-sensitive properties for targeted drug release. The mesoporous silica shell achieved long-term drug release, improving therapeutic effects. The nanoplatform provided a new strategy for the long-term treatment of tumors.
Developing the multifunctional nanocarriers for long-term drug release and luminescence traceability is a challenging assignment. In this task, we designed a novel nanoplatform for long-term and luminescence trackable chemotherapy, which is prepared via a hollow ZIF-8 (where ZIF is zeolitic imidazolate frameworks) coated by the Eu3+-doped mesoporous silica (ZIF-8@mesoporous silica). The hollow ZIF-8 is used as a drug library for loading the anticancer drug, and the pH-sensitive properties of ZIF-8 can targeted-release drugs in the tumor and cut down the poisonousness of drugs to normal cells. The shell layer of mesoporous silica can achieve the long-term drug release, which solves the problem of short drug circulation time in the body, reduces the drug administration frequency, and improves the therapeutic effect. Notably, the ZIF-8@mesoporous + doxorubicin (DOX) is injected only once during the 14-day chemotherapy. In addition, Eu3+_doped in mesoporous silica ensures luminescence tracking and detection of drug pathways in living cells. Hence, this nanoplatform provides a whole new strategy for the long-term treatment of tumors.
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