Pharmacological compounds targeting emotional cognition in alcohol use disorder: A systematic review

Non-emotional (e.g., executive functions) and emotional cognitive (e.g., facial emotion recognition) impairments are a well-known aspect of alcohol use disorder (AUD). These deficits may impede on treatment outcomes, increase the risk of relapse, and lead to socio-occupational disabilities. Previous systematic reviews have examined the effectiveness of cognitive enhancing pharmacological agents (CEPAs) targeting non-emotional, but not emotional, cognition in AUD. Our aim was to systematically review the effectiveness of CEPAs targeting emotional cognition in subclinical and clinical AUD populations. A qualitative synthesis of controlled trials was conducted, and the studies were assessed for risk of bias. Eight studies were eligible (15 <= ns <= 143), and they all had a moderate risk of bias. Modafinil and nalmefene were the most examined agents, with the findings suggesting a potential beneficial effect of the agents on implicit emotional domains (i.e., reward processing). Methodological shortcomings and heterogeneous findings across the studies do not allow inferences about the effectiveness of these compounds in AUD. Future studies should examine CEPAs targeting emotional cognition in more detail.

Automated summary

Non-emotional and emotional cognitive impairments are common in individuals with alcohol use disorder. This study aimed to review the effectiveness of cognitive enhancing pharmacological agents (CEPAs) targeting emotional cognition in individuals with subclinical and clinical AUD. Eight eligible studies were included, and Modafinil and nalmefene appeared to have potential beneficial effects on implicit emotional domains. However, methodological shortcomings and heterogeneous findings limit the conclusions about the effectiveness of these compounds in AUD.