Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 20, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2203024119
Keywords
mPFC; hippocampus; theta oscillations; behavior; memory retrieval
Categories
Funding
- National Agency of Scientific and Technological Promotion of Argentina [PICT 2015-2344, PICT 2018-1063, PICT 2014-2828, PICT 2017-2254]
- University of Buenos Aires
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Remembering life episodes is a complex process that requires interaction among multiple brain areas. The hippocampus activates the medial prefrontal cortex to trigger the recall of past events. Electrophysiological recordings showed increased synchronization between the ventral hippocampus and the medial prefrontal cortex during exploration of contextually mismatched objects.
Remembering life episodes is a complex process that requires interaction among multiple brain areas. It is thought that contextual information provided by the hippocampus (HPC) can trigger the recall of a past event through the activation of medial prefrontal cortex (mPFC) neuronal ensembles, but the underlying mechanisms remain poorly understood. However, little is known about the coordinated activity between these structures during recall. We performed electrophysiological recordings in behaving rats during the retrieval phase of the object-in-context (OIC) memory task. Context-guided recognition of objects in this task requires the activity of both the mPFC and the ventral HPC (vHPC). Coherence, phase locking, and theta amplitude correlation analysis showed an increase in vHPC-mPFC LFP synchronization in the theta range when animals explore contextually mismatched objects. Moreover, we identified ensembles of putative pyramidal cells in the mPFC that encode specific object-context associations. Interestingly, the increase of vHPC-mPFC synchronization during exploration of the contextually mismatched object and the preference of mPFC incongruent object neurons predicts the animals' performance during the resolution of the OIC task. Altogether, these results identify changes in vHPC-mPFC synchronization and mPFC ensembles encoding specific object-context associations likely involved in the recall of past events.
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