Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 20, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2200931119
Keywords
memory; sleep; replay
Categories
Funding
- NIH [MH107396, U19 NS107616, U19 NS104590]
- DFG [Exc 2049, SFB 1315, 390688087]
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The study found that sharp wave ripples (SPW-Rs) coincided with a transient brain-wide increase in functional connectivity, and the diversity in SPW-R features was correlated with their intrahippocampal topography along the septotemporal axis. Furthermore, variations in SPW-R features were related to the timing, sign, and magnitude of downstream responses.
During periods of disengagement from the environment, transient population bursts, known as sharp wave ripples (SPW-Rs), occur sporadically. While numerous experi-ments have characterized the bidirectional relationship between SPW-Rs and activity in chosen brain areas, the topographic relationship between different segments of the hip-pocampus and brain-wide target areas has not been studied at high temporal and spatial resolution. Yet, such knowledge is necessary to infer the direction of communication. We analyzed two publicly available datasets with simultaneous high-density silicon probe recordings from across the mouse forebrain. We found that SPW-Rs coincide with a transient brain-wide increase in functional connectivity. In addition, we show that the diversity in SPW-R features, such as their incidence, magnitude, and intrahip-pocampal topography in the septotemporal axis, are correlated with slower excitability fluctuations in cortical and subcortical areas. Further, variations in SPW-R features correlated with the timing, sign, and magnitude of downstream responses with large -amplitude SPW-Rs followed by transient silence in extrahippocampal structures. Our findings expand on previous results and demonstrate that the activity patterns in extra-hippocampal structures depend both on the intrahippocampal topographic origin and magnitude of hippocampal SPW-Rs.
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