Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 119, Issue 10, Pages -Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2120150119
Keywords
evolutionary developmental biology; fibroblast growth factor signaling; Hedgehog signaling; unpaired fin; median fin
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Funding
- NSF [IBN-0446720, IOS-1121855, IOS-1755305, IOS-1853949]
- Scientific Grant Agency of Slovak Republic [1/0450/21]
- Brinson Foundation
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By using chemical genetics, researchers have demonstrated a mutually agonistic interaction between Fgf and Shh genes in the developing dorsal fin of the channel catfish. They also found similar gene expression patterns in median fins of representatives from other major vertebrate lineages, supporting a median fin-first scenario for vertebrate paired appendage origins.
The origin and diversification of appendage types is a central question in vertebrate evolution. Understanding the genetic mechanisms that underlie fin and limb development can reveal relationships between different appendages. Here we demonstrate, using chemical genetics, a mutually agonistic interaction between Fgf and Shh genes in the developing dorsal fin of the channel catfish, Ictalurus punctatus. We also find that Fgf8 and Shh orthologs are expressed in the apical ectodermal ridge and zone of polarizing activity, respectively, in the median fins of representatives from other major vertebrate lineages. These findings demonstrate the importance of this feedback loop in median fins and offer developmental evidence for a median fin-first scenario for vertebrate paired appendage origins.
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